Protein Kinase CK2 Inhibitors: Emerging Anticancer Therapeutic Agents?

Title: Protein Kinase CK2 Inhibitors: Emerging Anticancer Therapeutic Agents?

Volume: 8 Issue: 7

Author(s): Andrea Bortolato, Giorgio Cozza and Stefano Moro

Affiliation:

Keywords: Protein kinase CK2, casein kinase 2, anticancer drugs, drug discovery

Abstract: Protein kinase CK2 is a ubiquitous, essential, and highly pleiotropic protein kinase whose abnormally high constitutive activity is suspected to underlie its pathogenic potential in neoplasia and other diseases. A number of structurally unrelated CK2 inhibitors, tested on a variety of cells derived from tumours, including lymphomas, leukaemias, multiple myeloma and prostate carcinoma, display a proapoptotic effect which is roughly proportional to their in vitro inhibitory potency. In the present review we summarize the most recent discovery of potent and selective CK2 inhibitors and their prospective as future anticancer agents.

Cite this article as:

Bortolato Andrea, Cozza Giorgio and Moro Stefano, Protein Kinase CK2 Inhibitors: Emerging Anticancer Therapeutic Agents?, Anti-Cancer Agents in Medicinal Chemistry 2008; 8 (7) . https://dx.doi.org/10.2174/187152008785914761