Abstract
Obesity is a complex disorder involving the excessive accumulation of fat in the body. It is the most common disorder worldwide, which leads to many complications like diabetes, strokes, and other cardiovascular disorders. The above complications cause one-third of all mortality worldwide. This problem arises due to the considerable variation between calorie ingestion and energy consumption. The treatment of obesity is mostly based upon equalizing the above difference. Several natural compounds are used for treating obesity. However, these natural compounds have some issues, such as low water solubility, chemical instability during processing and storage, and poor bioavailability due to structural complexity. Therapeutic nanocarriers, such as "Phytosomes", will help to overcome the above issues and can be a potent solution for delivering anti-obese herbal phytoconstituents. Phytosomes are little cell-like structures and are advanced herbal formulations that contain the bioactive phytoconstituents of herbal extract bounded by a lipid. There is no literature available with comprehensive details about anti-obesity herbal phytosomal formulations.
Objectives: This review provides a detailed review of the treatment of obesity with natural products that are formulated as phytosomes. When novel drug delivery technology is used instead of traditional drug delivery in herbal medicine, side effects are reduced while safety and efficacy are improved.This article provides information about obesity, its treatment, and special emphasis on phytosomes, their preparation, and evaluation along with their application in obesity.
Methods: A comprehensive search of electronic databases such as Medline, Embase, Cochrane Library, Google, and Google Patents was carried out.
Results: This review explains the details of research done on phytosomes with special reference to anti-obesity drugs. Still, there is a need to formulate anti-obesity herbal drugs as phytosomes to get better bioavailability and fewer side effects. This phytosomal drug delivery approach may resolve the problems associated with conventional drug delivery.
Conclusion: Integrating herbal medicine with novel drug delivery systems such as phytosomes to combat obesity has significant scope and importance.
Keywords: Anti-obesity, Phytosomes, Herbal, Phytoconstituents, Formulation, Review
Graphical Abstract
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