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Medicinal Chemistry

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ISSN (Online): 1875-6638

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Review Article

Recent Insights on Synthetic Methods and Pharmacological Potential in Relation with Structure of Benzothiazoles

Author(s): Ranjeet Kumar Yadav, Rajnish Kumar*, Himanshu Singh, Avijit Mazumdar, Salahuddin, Bharti Chauhan and Mohd. Mustaqeem Abdullah

Volume 19, Issue 4, 2023

Published on: 13 October, 2022

Page: [325 - 360] Pages: 36

DOI: 10.2174/1573406418666220820110551

Price: $65

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Abstract

Benzothiazole is a bicyclic heterocyclic compound that contains benzene fused with 1, 3- thiazole ring. Several researches established the potential of benzothiazoles as important moiety in various adverse pharmacological conditions. Benzothiazole and its derivatives have been in use and marketed as anti-microbial, anti-inflammatory, anti-diabetic, anti-oxidant, anti-convulsant, antitumor, etc. The variations in pharmacological potentials of benzothiazole and its derivatives have been rational with their chemical structure. Nowadays, hybridization of two or more pharmacophores to synthesize a single molecule with potent pharmacological action is used. This helps to synergize pharmacological properties, make interaction possible with many targets, or minimize the adverse effects associated with them. Several synthetic approaches have been reported for benzothiazole and its derivatives. In this present review article, we focused on recently adopted synthetic approaches for the synthesis of the benzothiazole nucleus and its derivatives. The structure-activity relationship in relation to different pharmacological activities has also been highlighted to provide a good understanding to the researchers for future research on benzothiazoles.

Keywords: Benzothiazole, Pharmacological potential, Chemical structure, Synthesis, Synthetic approach, Structure-activity relationship

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