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Current Medicinal Chemistry

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ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

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Review Article

Ferroptosis and Hydrogen Sulfide in Cardiovascular Disease

Author(s): Ze-Fan Wu, Bin-Jie Yan, Wen Luo, Dan-Dan Gui, Zhong Ren, Yun Ma and Zhi-Sheng Jiang*

Volume 30, Issue 16, 2023

Published on: 26 September, 2022

Page: [1848 - 1859] Pages: 12

DOI: 10.2174/0929867329666220630144648

Price: $65

Abstract

Ferroptosis is an iron-dependent cell death, characterized by the accumulation of lipid-reactive oxygen species; various regulatory mechanisms influence the course of ferroptosis. The rapid increase in cardiovascular diseases (CVDs) is an extremely urgent problem. CVDs are characterized by the progressive deterioration of the heart and blood vessels, eventually leading to circulatory system disorder. Accumulating evidence, however, has highlighted crucial roles of ferroptosis in CVDs. Hydrogen sulfide plays a significant part in anti-oxidative stress, which may participate in the general mechanism of ferroptosis and regulate it by some signaling molecules. This review has primarily summarized the effects of hydrogen sulfide on ferroptosis and cardiovascular disease, especially the antioxidative stress, and would provide a more effective direction for the clinical study of CVDs.

Keywords: Hydrogen sulfide, cardiovascular disease, ferroptosis, oxidative stress, signaling molecular, mechanism

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