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Mini-Reviews in Organic Chemistry

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ISSN (Print): 1570-193X
ISSN (Online): 1875-6298

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Mini-Review Article

Ten Years of Progress in the Synthesis of 2-Pyridone Derivatives via Three / Four Component Reaction

Author(s): Kebaili Asmaa, Belhadj Fatima*, Kibou Zahira and Choukchou-Braham Noureddine

Volume 20, Issue 4, 2023

Published on: 15 August, 2022

Page: [358 - 371] Pages: 14

DOI: 10.2174/1570193X19666220519090636

Price: $65

Abstract

2-pyridones represents ubiquitous scaffolds often present in both natural products and pharmaceutical compounds. Due to their wide applications in medicinal chemistry, it is not surprising that the synthesis of 2-pyridone derivatives has attracted organic chemists for many years. This mini review focuses on the recent development in the multi-component synthesis of 2-pyridones for the period 2011 to 2021, particularly those that involve the three/four component reactions of activated methylene, aldehyde or ketone withdifferent intermediate materials under different conditions.

Keywords: Organic chemistry, heterocyclic compounds, 2-pyridone, one-pot synthesis, three/four component reaction, green synthesis.

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