Recent Insights into Therapeutic Potential of Plant-Derived Flavonoids against
Cancer

Roohi      Mohi-ud-din; Reyaz   Hassan   Mir; Saba      Sabreen; Rafia      Jan; Faheem   Hyder   Pottoo; Inder   Pal   Singh
doi:10.2174/1871520622666220421094055
Abstract

Flavonoids, a class of polyphenolic secondary metabolites, are present in fruits, vegetables, beverages such as wine and tea abundantly. Flavonoids exhibit a diverse array of pharmacological activities, including anticancer activity, and are toxic to cancer cells but not harmful to healthy cells. Besides, humans and animals cannot synthesize flavonoids, which leads to a dramatic increase in the consumption of plant flavonoids. Flavonoids consist of a 15- carbon skeleton in C6-C3-C6 rings with divergent substitution patterns to form a series of compounds. Due to their multi-faceted mechanism of action by modulating various signaling pathways associated with apoptosis, cellular proliferation, inflammation, differentiation, metastasis, angiogenesis, they interrupt the initiation, promotion, and progression of cancer. The present review highlights the Structural Activity Relationship (SAR) of flavonoids and recent insights on the progress of natural flavonoids and their synthetic analogs as prospective drug candidates against cancer, along with molecular mechanisms of action.
Keywords: Flavonoids, anti-cancer, signaling pathways, apigenin, fisetin, morin, quercetin, isoflavones.
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DOI https://dx.doi.org/10.2174/1871520622666220421094055	Print ISSN 1871-5206
Publisher Name Bentham Science Publisher	Online ISSN 1875-5992
Anti-Cancer Agents in Medicinal Chemistry

Recent Insights into Therapeutic Potential of Plant-Derived Flavonoids against Cancer

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