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Current Organocatalysis

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ISSN (Print): 2213-3372
ISSN (Online): 2213-3380

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Research Article

Synthesis of Oxadiazole, Imidazole, Benzimidazole, Cyclohexano Analogues of 1, 5-benzodiazepines Through Phenoxyl/Phenylamino Linkage

Author(s): Mohd Amin Mir*

Volume 9, Issue 4, 2022

Published on: 03 October, 2022

Page: [297 - 304] Pages: 8

DOI: 10.2174/2212796816666220404151254

Price: $65

Abstract

Aims: The study aims to synthesize oxadiazole, imidazole, benzimidazole, and cyclohexano analogues of 1, 5-benzodiazepines through phenoxyl/phenylamino linkage.

Background: It is worthwhile to mention that imidazoles, benzimidazoles, oxadiazoles, are analysed extensively mainly as per their ready availability, broad chemical reactivity, and wide spectrum of biochemical activities, like antimicrobial, anti-inflammatory, antitumor, anticonvulsant drugs, antitubercular medicines, and having an anti-HIV effect, etc.

Objective: The oxadiazole, imidazole, benzimidazole derivatives were synthesized via cyclohexano analogues of 1, 5-benzodiazepines through phenoxyl/phenylamino linkage.

Methods: The characteristic drift of our interest towards these molecules prompted us to think about the structural modification of [1, 5]-benzodiazepine compound by incorporating on its 2-position imidazole, benzimidazole, oxadiazole, nuclei through an aminophenyl or phenoxyl bridge to synthesize these novel heterocyclic analogues of 1, 5-benzodiazepines.

Results: These derivatives have been analysed by various spectrophometric techniques like UV, IR, NMR, and MS. The synthesis of these compounds via the mentioned methods is unique as cyclohexano analogues of 1, 5-benzodiazepines through phenoxyl/phenylamino is a totally new way of synthesis. The derivatives can be analysed for various properties in chemistry and pharmacology, as their parent compounds have many pharmacological properties.

Conclusion: The synthesis of these types of compounds does provide new hope to the medicinal and pharmaceutical industries. Therefore further efforts should be taken into consideration for the synthesis and analysis of their medicinal properties.

Keywords: Oxadiazole, Imidazole, Benzimidazoles, 1, 5-benzodiazepines, phenoxyl / phenylamino linkage, IR, 1H NMR

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Graphical Abstract

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