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CNS & Neurological Disorders - Drug Targets

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ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

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Review Article

Importance of Pharmacophore in Designing Anticonvulsant Agents

Author(s): Amol Kale*, Rajendra Kakde, Smita Pawar, Vishal Jagtap and Rahul Dorugade

Volume 22, Issue 4, 2023

Published on: 21 July, 2022

Page: [500 - 511] Pages: 12

DOI: 10.2174/1871527321666220401115529

open access plus

Abstract

Drug design is one of the critical aspects of the drug development process. The present review focused on different heterocyclic molecules having anticonvulsant activity with structural diversity and common pharmacophoric features. For the first time (1995), Dimmock and his team introduced specific arrangements of three important pharmacophores for anticonvulsant activity. These pharmacophores include two hydrophobic binding sites and one hydrogen binding site. After a few years (2012), Pandeya modified Dimmock’s concept by adding one more pharmacophoric feature as an electron donor in the previously suggested pharmacophoric arrangement of the anticonvulsant. As a result, numerous scientists designed anticonvulsant drugs based on Dimmock’s and Pandeya’s concept. In addition, marketed anticonvulsant preparation containing Riluzole, Phenobarbital, Progabide, Ralitoline, etc., also holds the suggested pharmacophores by Dimmock and Pandeya’s pharmacophoric concept. This review mainly focuses on the compilation of reported scientific literature in the last decade on the pharmacophoric features of different heterocyclic anticonvulsants, which will help develop new anticonvulsants.

Keywords: Pharmacophore models, anticonvulsant, maximal electroshock seizure, drug development, electron donor, pharmacophoric features.

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