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CNS & Neurological Disorders - Drug Targets

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ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

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Review Article

Inter/Transgenerational Effects of Drugs of Abuse: A Scoping Review

Author(s): Mitra-Sadat Sadat-Shirazi, Mahsa Sadeghi-Adl, Ardeshir Akbarabadi, Ghorbangol Ashabi, Azarakhsh Mokri and Mohammad-Reza Zarrindast*

Volume 22, Issue 4, 2023

Published on: 14 June, 2022

Page: [512 - 538] Pages: 27

DOI: 10.2174/1871527321666220429122819

open access plus

Abstract

Drug addiction is a chronic relapsing disorder that makes it a global problem. Genetics and environmental factors are the two most important factors that make someone vulnerable to drug addiction. Investigations in the past decade highlighted the role of epigenetics in the inter/transgenerational inheritance of drug addiction. A growing body of evidence showed that parental (paternal, maternal, and biparental) drug exposure before conception changes the phenotype of the offspring, which is correlated with neurochemical and neurostructural changes in the brain. The current paper reviews the effects of parental (maternal, paternal, and biparental) exposure to drugs of abuse (opioids, cocaine, nicotine, alcohol, and cannabis) before gestation in animal models.

Keywords: Transgeneration, opioid, cocaine, cannabis, nicotine, ethanol, parental.

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Graphical Abstract

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