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Current Cancer Therapy Reviews

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ISSN (Print): 1573-3947
ISSN (Online): 1875-6301

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Review Article

Biological Activities and Therapeutic Potential of Irigenin on Gastric, Lung, Prostate, Breast, and Endometrial Cancer: Pharmacological and Analytical Aspects

Author(s): Dinesh Kumar Patel*

Volume 18, Issue 3, 2022

Published on: 22 July, 2022

Page: [172 - 180] Pages: 9

DOI: 10.2174/1573394718666220329184852

Price: $65

Abstract

Background: Herbal medicines have been used for thousands of years due to their pharmacological activities against different types of human disorders. The biological effectiveness and pharmacological activities of herbal medicines are mainly due to the presence of different kinds of phytoconstituents, commonly called secondary metabolites. Isoflavones are naturally present in different types of plants and food materials, and most of these phytocompounds have a wide range of biological activities, including anti-tumor, anti-proliferative, anti-inflammatory, anti-microbial, antiviral, anti-oxidant, and estrogen-like activities.

Methods: Irigenin isolated from the rhizome of Belamcanda chinensis and the genus Iris showed a wide range of biological activities. Due to the huge biological potential and the therapeutic benefits of irigenin in medicine, here in the present investigation, scientific research data on irigenin has been collected from different literature sources (Science Direct, Google Scholar, PubMed, Google) and analyzed in order to know the therapeutic potential of irigenin in medicine. Scientific data on the pharmacological activities of irigenin have been collected from Science Direct, Google Scholar, PubMed, and Google databases and analyzed in the present work. The importance of different analytical techniques for the isolation and separation of irigenin has also been discussed and presented in the current work.

Results: Scientific data analysis of different research works revealed the biological importance of irigenin in medicine. Irigenin is an O-methylated isoflavone found to be present in the Belamcanda chinensis and genus Iris. Scientific data analysis revealed the biological importance of irigenin against gastric cancer, lung carcinoma, prostate cancer, breast cancer, endometrial cancer, diabetic complications, inflammation, and cardiac injury. Analytical data on irigenin revealed the importance of analytical techniques for the separation, isolation, and identification of irigenin from various biological samples.

Conclusion: Scientific data analysis of different research works revealed the biological importance and therapeutic potential of irigenin in medicine.

Keywords: Irigenin, gastric cancer, lung carcinoma, prostate cancer, breast cancer, endometrial cancer, diabetic complications, inflammation, cardiac injury.

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[1]
Bu F, Zhang S, Duan Z, et al. A critical review on the relationship of herbal medicine, Akkermansia muciniphila, and human health. Biomed Pharmacother 2020; 128: 110352.
[http://dx.doi.org/10.1016/j.biopha.2020.110352] [PMID: 32521456]
[2]
Patel K, Kumar V, Rahman M, Verma A, Patel DK. Rhamnazin: A systematic review on ethnopharmacology, pharmacology and analytical aspects of an important phytomedicine. Curr Tradit Med 2018; 4(2): 120-7.
[http://dx.doi.org/10.2174/2215083804666180416124949]
[3]
Patel DK, Patel K, Rahman M, Chaudhary S. Therapeutic potential of “Aegeline,” an important phytochemical of Aegle marmelos. In: current health perspectives for the treatment of disease nanomedicine bioact. Singapore: Springer Singapore 2020; pp. 383-92.
[4]
Ji X, Shi S, Liu B, et al. Bioactive compounds from herbal medicines to manage dyslipidemia. Biomed Pharmacother 2019; 118: 109338.
[http://dx.doi.org/10.1016/j.biopha.2019.109338] [PMID: 31545238]
[5]
Yin S, Sun C, Ji Y, Abdolmaleky H, Zhou J-R. Herbal medicine WangShiBaoChiWan improves gastrointestinal health in mice via modula-tion of intestinal tight junctions and gut microbiota and inhibition of inflammation. Biomed Pharmacother 2021; 138: 111426.
[http://dx.doi.org/10.1016/j.biopha.2021.111426] [PMID: 33762124]
[6]
Casteleijn D, Steel A, Bowman D, Lauche R, Wardle J. A naturalistic study of herbal medicine for self-reported depression and/or anxiety a protocol. Integr Med Res 2019; 8(2): 123-8.
[http://dx.doi.org/10.1016/j.imr.2019.04.007] [PMID: 31193603]
[7]
Kim M, Woo Y, Han CH. Current status of the spontaneous reporting and classification/coding system for herbal and traditional medicine in pharmacovigilance. Integr Med Res 2021; 10(1): 100467.
[http://dx.doi.org/10.1016/j.imr.2020.100467] [PMID: 32802741]
[8]
Patel K, Rahman M, Kumar V, Verma A, Patel DK. Visnagin: A new perspective of medicinal importance, physiological functions, phyto-chemistry, pharmacology and analytical aspects of active phytoconstituents of Ammi visnaga. Nat Prod J 2019; 9(3): 197-206.
[http://dx.doi.org/10.2174/2210315508666180327154245]
[9]
Wu Y, Sun L, Zeng F, Wu S. A conjugated-polymer-based ratiometric nanoprobe for evaluating in-vivo hepatotoxicity induced by herbal medicine via MSOT imaging. Photoacoustics 2018; 13: 6-17.
[http://dx.doi.org/10.1016/j.pacs.2018.11.002] [PMID: 30519528]
[10]
Chen L, Mulder PPJ, Peijnenburg A, Rietjens IMCM. Risk assessment of intake of pyrrolizidine alkaloids from herbal teas and medicines following realistic exposure scenarios. Food Chem Toxicol 2019; 130: 142-53.
[http://dx.doi.org/10.1016/j.fct.2019.05.024] [PMID: 31112705]
[11]
Patel K, Gadewar M, Tahilyani V, Patel DK. A review on pharmacological and analytical aspects of diosmetin: A concise report. Chin J Integr Med 2013; 19(10): 792-800.
[http://dx.doi.org/10.1007/s11655-013-1595-3] [PMID: 24092244]
[12]
Fu M. Drug discovery from traditional Chinese herbal medicine using high content imaging technology. J Tradit Chinese Med Sci 2021; 8(3): 198-204.
[http://dx.doi.org/10.1016/j.jtcms.2021.07.005]
[13]
Pu H, Li X, Du Q, Cui H, Xu Y. Research progress in the application of Chinese herbal medicines in aquaculture: A review. Engineering (Beijing) 2017; 3(5): 731-7.
[http://dx.doi.org/10.1016/J.ENG.2017.03.017]
[14]
Xu A, Shang-Guan J, Li Z, Gao Z, Huang YC, Chen Q. Effects of dietary Chinese herbal medicines mixture on feeding attraction activity, growth performance, nonspecific immunity and digestive enzyme activity of Japanese seabass (Lateolabrax japonicus). Aquacult Rep 2020; 17: 100304.
[http://dx.doi.org/10.1016/j.aqrep.2020.100304]
[15]
Wani SH, Bhat HA, Mir JI, et al. Quantitative analysis of irigenin in the different species of iris plant by RP- HPLC and its efficacy against different plant pathogens. Pharmacogn J 2017; 9(6s): s23-7.
[http://dx.doi.org/10.5530/pj.2017.6s.153]
[16]
Patel K, Kumar V, Verma A, Rahman M, Patel DK. Amarogentin as topical anticancer and anti-infective potential: Scope of lipid based vesicular in its effective delivery. Recent Pat Antiinfect Drug Discov 2019; 14(1): 7-15.
[http://dx.doi.org/10.2174/1574891X13666180913154355] [PMID: 30210007]
[17]
Hikita K, Saigusa S, Takeuchi Y, et al. Induction of enantio-selective apoptosis in human leukemia HL-60 cells by (S)-erypoegin K, an isoflavone isolated from Erythrina poeppigiana. Bioorg Med Chem 2020; 28(11): 115490.
[http://dx.doi.org/10.1016/j.bmc.2020.115490] [PMID: 32299660]
[18]
Patel K, Patel DK. Therapeutic benefit and biological importance of ginkgetin in the medicine: Medicinal importance, pharmacological activities and analytical aspects. Curr Bioact Compd 2021; 17(9): 17.
[http://dx.doi.org/10.2174/1573407217666210127091221]
[19]
Patel DK. Biological importance, therapeutic benefit and analytical aspects of bioactive flavonoid pectolinarin in the nature. Drug Metab Lett 2021; 14(2): 117-25.
[http://dx.doi.org/10.2174/1872312814666210726112910] [PMID: 34313205]
[20]
Hsiao Y-H, Ho C-T, Pan M-H. Bioavailability and health benefits of major isoflavone aglycones and their metabolites. J Funct Foods 2020; 74: 104164.
[http://dx.doi.org/10.1016/j.jff.2020.104164]
[21]
Pei R, Zhang J, Tian L, et al. Identification of novel QTL associated with soybean isoflavone content. Crop J 2018; 6(3): 244-52.
[http://dx.doi.org/10.1016/j.cj.2017.10.004]
[22]
Reis A, Scopel M, Zuanazzi JAS. Trifolium pratense: Friable calli, cell culture protocol and isoflavones content in wild plants, in vitro and cell cultures analyzed by UPLC. Rev Bras Farmacogn 2018; 28(5): 542-50.
[http://dx.doi.org/10.1016/j.bjp.2018.06.004]
[23]
Patel K, Kumar V, Rahman M, Verma A, Patel DK. New insights into the medicinal importance, physiological functions and bioanalytical aspects of an important bioactive compound of foods ‘Hyperin’: Health benefits of the past, the present, the future. Beni Suef Univ J Basic Appl Sci 2018; 7(1): 31-42.
[http://dx.doi.org/10.1016/j.bjbas.2017.05.009]
[24]
Morales-de la Peña M, Martín-Belloso O, Welti-Chanes J. High-power ultrasound as pre-treatment in different stages of soymilk manufac-turing process to increase the isoflavone content. Ultrason Sonochem 2018; 49: 154-60.
[http://dx.doi.org/10.1016/j.ultsonch.2018.07.044] [PMID: 30077475]
[25]
Ochensberger S, Alperth F, Mitić B, et al. Phenolic compounds of Iris adriatica and their antimycobacterial effects. Acta Pharm 2019; 69(4): 673-81.
[http://dx.doi.org/10.2478/acph-2019-0037] [PMID: 31639092]
[26]
Guo L, Zheng X, Wang E, Jia X, Wang G, Wen J. Irigenin treatment alleviates doxorubicin (DOX)-induced cardiotoxicity by suppressing apoptosis, inflammation and oxidative stress via the increase of miR-425. Biomed Pharmacother 2020; 125: 109784.
[http://dx.doi.org/10.1016/j.biopha.2019.109784] [PMID: 32092815]
[27]
Ahn KS, Noh EJ, Cha K-H, et al. Inhibitory effects of Irigenin from the rhizomes of Belamcanda chinensis on nitric oxide and prostaglan-din E(2) production in murine macrophage RAW 264.7 cells. Life Sci 2006; 78(20): 2336-42.
[http://dx.doi.org/10.1016/j.lfs.2005.09.041] [PMID: 16307761]
[28]
Wollenweber E, Stevens JF, Klimo K, Knauft J, Frank N, Gerhäuser C. Cancer chemopreventive in vitro activities of isoflavones isolated from Iris germanica. Planta Med 2003; 69(1): 15-20.
[http://dx.doi.org/10.1055/s-2003-37030] [PMID: 12567273]
[29]
Liu M, Yang S, Jin L, Hu D, Wu Z, Yang S. Chemical constituents of the ethyl acetate extract of Belamcanda chinensis (L.) DC roots and their antitumor activities. Molecules 2012; 17(5): 6156-69.
[http://dx.doi.org/10.3390/molecules17056156] [PMID: 22627971]
[30]
Conforti F, Menichini F, Rigano D, Senatore F. Antiproliferative activity on human cancer cell lines after treatment with polyphenolic compounds isolated from Iris pseudopumila flowers and rhizomes. Z Naturforsch C J Biosci 2009; 64(7-8): 490-4.
[http://dx.doi.org/10.1515/znc-2009-7-804] [PMID: 19791498]
[31]
Xu Y, Gao CC, Pan ZG, Zhou CW. Irigenin sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells. Biochem Biophys Res Commun 2018; 496(3): 998-1005.
[http://dx.doi.org/10.1016/j.bbrc.2018.01.003] [PMID: 29305260]
[32]
Amin A, Chikan NA, Mokhdomi TA, et al. Irigenin, a novel lead from Western Himalayan chemiome inhibits Fibronectin-Extra Domain A induced metastasis in lung cancer cells. Sci Rep 2016; 6(1): 37151.
[http://dx.doi.org/10.1038/srep37151] [PMID: 27849000]
[33]
Morrissey C, Bektic J, Spengler B, et al. Phytoestrogens derived from Belamcanda chinensis have an antiproliferative effect on prostate cancer cells in vitro. J Urol 2004; 172(6 Pt 1): 2426-33.
[http://dx.doi.org/10.1097/01.ju.0000143537.86596.66] [PMID: 15538285]
[34]
Kwon A, Chae IH, You E, et al. Extra domain A-containing fibronectin expression in Spin90-deficient fibroblasts mediates cancer-stroma interaction and promotes breast cancer progression. J Cell Physiol 2020; 235(5): 4494-507.
[http://dx.doi.org/10.1002/jcp.29326] [PMID: 31637720]
[35]
Monthakantirat O, De-Eknamkul W, Umehara K, et al. Phenolic constituents of the rhizomes of the Thai medicinal plant Belamcanda chinensis with proliferative activity for two breast cancer cell lines. J Nat Prod 2005; 68(3): 361-4.
[http://dx.doi.org/10.1021/np040175c] [PMID: 15787436]
[36]
O’Toole SA, Sheppard BL, Sheils O, O’Leary JJ, Spengler B, Christoffel V. Analysis of DNA in endometrial cancer cells treated with phy-to-estrogenic compounds using comparative genomic hybridisation microarrays. Planta Med 2005; 71(5): 435-9.
[http://dx.doi.org/10.1055/s-2005-864139] [PMID: 15931582]
[37]
Jung SH, Lee YS, Lee S, Lim SS, Kim YS, Shin KH. Isoflavonoids from the rhizomes of Belamcanda chinensis and their effects on aldose reductase and sorbitol accumulation in streptozotocin induced diabetic rat tissues. Arch Pharm Res 2002; 25(3): 306-12.
[http://dx.doi.org/10.1007/BF02976631] [PMID: 12135102]
[38]
Ibrahim SRM, Mohamed GA, Zayed MF, Ross SA. 8-Hydroxyirilone 5-methyl ether and 8-hydroxyirilone, new antioxidant and α-amylase inhibitors isoflavonoids from Iris germanica rhizomes. Bioorg Chem 2017; 70: 192-8.
[http://dx.doi.org/10.1016/j.bioorg.2016.12.010] [PMID: 28069265]
[39]
Li S, Li S, Huang Y, Liu C, Chen L, Zhang Y. Ionic-liquid-based ultrasound-assisted extraction of isoflavones from Belamcanda chinensis and subsequent screening and isolation of potential α-glucosidase inhibitors by ultrafiltration and semipreparative high-performance liquid chromatography. J Sep Sci 2017; 40(12): 2565-74.
[http://dx.doi.org/10.1002/jssc.201700258] [PMID: 28444982]
[40]
Zhang WD, Yang WJ, Wang XJ, Gu Y, Wang R. Simultaneous determination of tectorigenin, irigenin and irisflorentin in rat plasma and urine by UHPLC-MS/MS: Application to pharmacokinetics. J Chromatogr B Analyt Technol Biomed Life Sci 2011; 879(31): 3735-41.
[http://dx.doi.org/10.1016/j.jchromb.2011.10.022] [PMID: 22071270]
[41]
Li L, Zhang X, Bu F, Chen N, Zhang H, Gu J. Simultaneous determination of eight constituents in rat plasma by HPLC-MS/MS and its application to a pharmacokinetic study after oral administration of Shejin-liyan Granule. Biomed Chromatogr 2019; 33(11): e4648.
[http://dx.doi.org/10.1002/bmc.4648] [PMID: 31301083]
[42]
Mao H, Ye X, Chen W, Geng W, Chen G. Fabrication of carbon nanotube-polylactic acid composite electrode by melt compounding for capillary electrophoretic determination of tectoridin and irigenin in Belamcandae Rhizoma. J Pharm Biomed Anal 2019; 175: 112769.
[http://dx.doi.org/10.1016/j.jpba.2019.07.017] [PMID: 31398628]
[43]
Gu J, Wu W, Huang M, Long F, Liu X, Zhu Y. Application of high-performance liquid chromatography coupled with linear ion trap quad-rupole orbitrap mass spectrometry for qualitative and quantitative assessment of shejin-liyan granule supplements. Molecules 2018; 23(4): 884.
[http://dx.doi.org/10.3390/molecules23040884] [PMID: 29641474]
[44]
Wen Y, He L, Peng R, et al. A novel strategy to evaluate the quality of herbal products based on the chemical profiling, efficacy evaluation and pharmacokinetics. J Pharm Biomed Anal 2018; 161: 326-35.
[http://dx.doi.org/10.1016/j.jpba.2018.08.047] [PMID: 30196209]
[45]
Ibrahim SRM, Mohamed GA, Al-Musayeib NM. New constituents from the rhizomes of Egyptian Iris germanica L. Molecules 2012; 17(3): 2587-98.
[http://dx.doi.org/10.3390/molecules17032587] [PMID: 22388969]
[46]
Jia Y-W, Zeng Z-Q, Shi H-L, et al. Characterization of in vitro metabolites of irisflorentin by rat liver microsomes using high-performance liquid chromatography coupled with tandem mass spectrometry. Biomed Chromatogr 2016; 30(9): 1363-70.
[http://dx.doi.org/10.1002/bmc.3692] [PMID: 26840210]
[47]
Zhu Y, Pu B-Q, Xie G-Y, Tian M, Xu F-Y, Qin M-J. Dynamic changes of flavonoids contents in the different parts of rhizome of Belam-canda chinensis during the thermal drying process. Molecules 2014; 19(7): 10440-54.
[http://dx.doi.org/10.3390/molecules190710440] [PMID: 25036154]
[48]
Roger B, Jeannot V, Fernandez X, Cerantola S, Chahboun J. Characterisation and quantification of flavonoids in Iris germanica L. and Iris pallida Lam. resinoids from Morocco. Phytochem Anal 2012; 23(5): 450-5.
[http://dx.doi.org/10.1002/pca.1379] [PMID: 22213588]
[49]
Mahmood U, Kaul VK, Jirovetz L. Alkylated benzoquinones from Iris kumaonensis. Phytochemistry 2002; 61(8): 923-6.
[http://dx.doi.org/10.1016/S0031-9422(02)00474-0] [PMID: 12453518]
[50]
Zhang Y-Y, Wang Q, Qi L-W, Qin X-Y, Qin M-J. Characterization and determination of the major constituents in Belamcandae Rhizoma by HPLC-DAD-ESI-MS(n). J Pharm Biomed Anal 2011; 56(2): 304-14.
[http://dx.doi.org/10.1016/j.jpba.2011.05.040] [PMID: 21715119]
[51]
Xie GY, Chen YJ, Wen R, Xu JY, Wu SS, Qin MJ. [Chemical constituents from rhizomes of Iris germanica. Zhongguo Zhongyao Zazhi 2014; 39(5): 846-50.
[PMID: 25204177]
[52]
Lee YS, Kim SH, Kim JK, Lee S, Jung SH, Lim SS. Preparative isolation and purification of seven isoflavones from Belamcanda chinen-sis. Phytochem Anal 2011; 22(5): 468-73.
[http://dx.doi.org/10.1002/pca.1306] [PMID: 21465599]
[53]
Li S, Li S, Tang Y, Liu C, Chen L, Zhang Y. Ultrafiltration-LC-MS combined with semi-preparative HPLC for the simultaneous screening and isolation of lactate dehydrogenase inhibitors from Belamcanda chinensis. J Sep Sci 2016; 39(23): 4533-43.
[http://dx.doi.org/10.1002/jssc.201600703] [PMID: 27734585]
[54]
Li J, Li WZM, Huang W, et al. Quality evaluation of Rhizoma Belamcandae (Belamcanda chinensis (L.) DC.) by using high-performance liquid chromatography coupled with diode array detector and mass spectrometry. J Chromatogr A 2009; 1216(11): 2071-8.
[http://dx.doi.org/10.1016/j.chroma.2008.05.082] [PMID: 18550076]
[55]
Peng C, Liang Y, Wang X, Xie H, Zhang T, Ito Y. Preparative isolation and purification of flavonoids from the Chinese medicinal herb Belamcanda by high-speed countercurrent chromatography. J Liq Chromatogr Relat Technol 2009; 32(16): 2451-61.
[http://dx.doi.org/10.1080/10826070903188245] [PMID: 20046920]
[56]
Kang SW, Kim MC, Kim CY, Jung SH, Um BH. The rapid identification of isoflavonoids from Belamcanda chinensis by LC-NMR and LC-MS. Chem Pharm Bull (Tokyo) 2008; 56(10): 1452-4.
[http://dx.doi.org/10.1248/cpb.56.1452] [PMID: 18827388]
[57]
Ma L, Song ZW, Wu F. [Determination of five isoflavones in Belamcanda chinensis by RP-HPLC] Yao Xue Xue Bao 1996; 31(12): 945-9.
[PMID: 9863225]
[58]
Liu W, Luo J, Kong L. Application of complexation high-speed counter-current chromatography in the separation of 5-hydroxyisoflavone isomers from Belamcanda chinensis (L.) DC. J Chromatogr A 2011; 1218(14): 1842-8.
[http://dx.doi.org/10.1016/j.chroma.2011.02.011] [PMID: 21376332]
[59]
Jiang Y, Zhao W, Feng C, Zhou T, Fan G, Wu Y. Isolation and purification of isoflavonoids from Rhizoma Belamcandae by two-dimensional preparative high-performance liquid chromatography with column switch technology. Biomed Chromatogr 2009; 23(10): 1064-72.
[http://dx.doi.org/10.1002/bmc.1224] [PMID: 19382246]
[60]
Sun G, Wan Y, Sun Y. Study on the fingerprints of Belamcanda chinensis (L.) DC by capillary electrophoresis. Se Pu 2004; 22(3): 206-9.
[PMID: 15712898]
[61]
Wu YX, Xu LX. Analysis of isoflavones in Belamcanda chinensis (L.)DC. and Iris tectorum Maxim by square wave voltammetry. Yao Xue Xue Bao 1992; 27(1): 64-8.
[PMID: 1529717]
[62]
Dar BA, Lone SH, Shah WA, Bhat KA. LC-MS guided isolation of bioactive principles from iris hookeriana and bioevaluation of isolates for antimicrobial and antioxidant activities. Drug Res (Stuttg) 2016; 66(8): 427-31.
[http://dx.doi.org/10.1055/s-0042-108337] [PMID: 27281447]
[63]
Ha DT, Binh BT, Thu NT, Bich Thu NT, Thanh Tung PH, Oh WK. Four new compounds isolated from the aerial Part of Belamcanda chinensis (L.) and their effect on Vascular Smooth Muscle Cell (VSMC) proliferation. Chem Pharm Bull (Tokyo) 2019; 67(1): 41-6.
[http://dx.doi.org/10.1248/cpb.c18-00645] [PMID: 30606949]
[64]
Wozniak D, Janda B, Kapusta I, Oleszek W, Matkowski A. Antimutagenic and anti-oxidant activities of isoflavonoids from Belamcanda chinensis (L.) DC. Mutat Res 2010; 696(2): 148-53.
[http://dx.doi.org/10.1016/j.mrgentox.2010.01.004] [PMID: 20096370]
[65]
Michikawa T, Yamazaki S, Ono M, et al. Isoflavone intake in early pregnancy and hypospadias in the Japan environment and children’s study. Urology 2019; 124: 229-36.
[http://dx.doi.org/10.1016/j.urology.2018.11.008] [PMID: 30447265]
[66]
Patel K, Kumar V, Verma A, Rahman M, Patel DK. β-sitosterol: Bioactive compounds in foods, their role in health promotion and disease prevention “a concise report of its phytopharmaceutical importance”. Curr Tradit Med 2017; 3(3): 168-77.
[http://dx.doi.org/10.2174/2215083803666170615111759]
[67]
Patel K, Kumar V, Verma A, Rahman M, Kumar Patel D. Health benefits of furanocoumarins ‘Psoralidin’ an active phytochemical of Pso-ralea corylifolia: The present, past and future scenario. Curr Bioact Compd 2019; 15(4): 369-76.
[http://dx.doi.org/10.2174/1573407214666180511153438]
[68]
Patel K, Patel DK. Medicinal importance, pharmacological activities, and analytical aspects of hispidulin: A concise report. J Tradit Complement Med 2016; 7(3): 360-6.
[http://dx.doi.org/10.1016/j.jtcme.2016.11.003] [PMID: 28725632]
[69]
Sharma V, Janmeda P. Extraction, isolation and identification of flavonoid from Euphorbia neriifolia leaves. Arab J Chem 2017; 10(4): 509-14.
[http://dx.doi.org/10.1016/j.arabjc.2014.08.019]
[70]
Cragg GM, Newman DJ. Natural products: A continuing source of novel drug leads. Biochim Biophys Acta 2013; 1830(6): 3670-95.
[http://dx.doi.org/10.1016/j.bbagen.2013.02.008] [PMID: 23428572]

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