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Review Article

褪黑激素对椎间盘的抗退变作用:对炎症、氧化应激、凋亡和自噬的保护作用

卷 23, 期 7, 2022

发表于: 21 February, 2022

页: [711 - 718] 页: 8

弟呕挨: 10.2174/1389450123666220114151654

价格: $65

摘要

椎间盘（IVD）退化是下腰痛的主要原因。虽然IVD退化 （IVDD）的病因尚不清楚，但过度的氧化应激、炎症和凋亡以及自噬破坏在IVDD的发病机制中发挥着重要作用。因此，找到缓解这些过程的解决方案可以停止或减少IVDD的发展。褪黑素是一种强大的抗氧化剂，在调节软骨组织止血方面起着重要作用。褪黑激素抑制椎间盘细胞外基质（ECM）的破坏。褪黑激素通过抑制基质降解酶(如MMP-13)来保存ECM含量，包括sox-9、aggrecan和collagen II。这些保护作用可能是通过抑制IVD细胞的氧化应激、炎症和凋亡以及调节细胞自噬来实现的。

关键词: 褪黑素，椎间盘退变，氧化应激，炎症，凋亡，自噬。

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