Abstract
Increasing drug resistance among bacteria, fungi and other pathogenic microbes and the remarkable increase in the incidence of fungal infections like dermatomycoses in the world population underscore our inadequacy to deal with them. Thus there is an urgent need to search chemically novel, natural, renewable and safe anti-microbial substances that can offer opportunity for innovation of new drugs to combat the widespread dermatomycoses. Six fungal endophytic strains (Scytalidium sp. MCPL AzF 023, Pestalotiopsis sp. MCPL AzB 153, Colletotrichum sp. MCPL AzR 249, Alternaria sp. MCPL AzL 198, Nigrospora sp. MCPL AzS 076, and Chloridium sp. MCPL AzR 142) from Azadirachta indica A Juss were screened and evaluated their efficacy against dermatophytes Trichophyton and Microsporum. The susceptibility test was performed by whole plate diffusion method. The EtOAc extracted Scytalidium, Chloroform extracted Nigrospora, Colletotrichum, and Alternaria, ethyl ether extracted Nigrospora in particular significantly reduced the growth of dermatophytes. The MIC ranged from 125-400 μg ml-1 for Trichophyton and 200-350 μg ml-1 for Microsporum while the MFC ranged from 230 to 425 μg ml-1. The chloroform, EtOAc, and ethyl ether were the solvents that might dissolve major active fractions of Pestalotiopsis, Scytalidium and Chloridium. The growth patterns of dermatophytes were also significantly distorted at concentration of 100 μg ml-1 (below MIC), which is statistically significant with reference to untreated fungi. In this study, we recovered bioactive fractions that might be chemically novel and effective against dermatophytes particularly and on other human and plant pathogens in general. Thus we might anticipate some new bioactive compounds to design new effective drugs against dermatomycoses initially.
Current Bioactive Compounds
Title: Selection of Natural Strains of Fungal Endophytes from Azadirachta indica A. Juss, with Anti-Microbial Activity Against Dermatophytes
Volume: 4 Issue: 1
Author(s): V. C. Verma, S. K. Gond, Ashish Mishra, A. Kumar and R. N. Kharwar
Affiliation:
Abstract: Increasing drug resistance among bacteria, fungi and other pathogenic microbes and the remarkable increase in the incidence of fungal infections like dermatomycoses in the world population underscore our inadequacy to deal with them. Thus there is an urgent need to search chemically novel, natural, renewable and safe anti-microbial substances that can offer opportunity for innovation of new drugs to combat the widespread dermatomycoses. Six fungal endophytic strains (Scytalidium sp. MCPL AzF 023, Pestalotiopsis sp. MCPL AzB 153, Colletotrichum sp. MCPL AzR 249, Alternaria sp. MCPL AzL 198, Nigrospora sp. MCPL AzS 076, and Chloridium sp. MCPL AzR 142) from Azadirachta indica A Juss were screened and evaluated their efficacy against dermatophytes Trichophyton and Microsporum. The susceptibility test was performed by whole plate diffusion method. The EtOAc extracted Scytalidium, Chloroform extracted Nigrospora, Colletotrichum, and Alternaria, ethyl ether extracted Nigrospora in particular significantly reduced the growth of dermatophytes. The MIC ranged from 125-400 μg ml-1 for Trichophyton and 200-350 μg ml-1 for Microsporum while the MFC ranged from 230 to 425 μg ml-1. The chloroform, EtOAc, and ethyl ether were the solvents that might dissolve major active fractions of Pestalotiopsis, Scytalidium and Chloridium. The growth patterns of dermatophytes were also significantly distorted at concentration of 100 μg ml-1 (below MIC), which is statistically significant with reference to untreated fungi. In this study, we recovered bioactive fractions that might be chemically novel and effective against dermatophytes particularly and on other human and plant pathogens in general. Thus we might anticipate some new bioactive compounds to design new effective drugs against dermatomycoses initially.
Export Options
About this article
Cite this article as:
Verma C. V., Gond K. S., Mishra Ashish, Kumar A. and Kharwar N. R., Selection of Natural Strains of Fungal Endophytes from Azadirachta indica A. Juss, with Anti-Microbial Activity Against Dermatophytes, Current Bioactive Compounds 2008; 4 (1) . https://dx.doi.org/10.2174/157340708784533401
DOI https://dx.doi.org/10.2174/157340708784533401 |
Print ISSN 1573-4072 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6646 |

- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Endothelial Dysfunction in Heart Failure: Mechanisms and Therapeutic Approaches
Current Vascular Pharmacology Preface
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Selective Activation of Intracellular Signalling Pathways in Dendritic Cells for Cancer Immunotherapy
Anti-Cancer Agents in Medicinal Chemistry Omega-3 Fatty Acids Supplementation in Psychiatric Disorders: A Systematic Review
Current Psychopharmacology TGF-Beta: a Master Switch in Tumor Immunity
Current Pharmaceutical Design Recent Approaches Targeting Beta-Amyloid for Therapeutic Intervention of Alzheimer's disease
Recent Patents on CNS Drug Discovery (Discontinued) Monocyte and Macrophage Dysfunction as a Cause of HIV-1 Induced Dysfunction of Innate Immunity
Current Molecular Medicine From Virus Evolution to Vector Revolution: Use of Naturally Occurring Serotypes of Adeno-associated Virus (AAV) as Novel Vectors for Human Gene Therapy
Current Gene Therapy Development and Evaluation of Bioresponsive Tablets of a Selective COX-2 Inhibitor for Colonic Delivery
Drug Delivery Letters 6-Chloro-7-methyl-3', 4'-dimethoxyflavone – a Potent Selective COX-2 Inhibitor
Medicinal Chemistry Genetic and Environmental Factors in Complex Neurodevelopmental Disorders
Current Genomics Genetically Engineered Bacteriocins and their Potential as the Next Generation of Antimicrobials
Current Pharmaceutical Design Stinging Insect Allergens
Current Protein & Peptide Science Pain Biomarkers in Cancer: An Overview
Current Pharmaceutical Design Resveratrol and Ischemic Preconditioning in the Brain
Current Medicinal Chemistry Effect of Different Carriers on In Vitro and In Vivo Drug Release Behavior of Aceclofenac Proniosomes
Current Drug Delivery Cancer Genetics and Drug Discovery in Mice
Letters in Drug Design & Discovery Potential Adverse Effects Associated with Inhibition of p38α/β MAP Kinases
Current Topics in Medicinal Chemistry Sublethal Total Body Irradiation Leads to Early Cerebellar Damage and Oxidative Stress
Current Neurovascular Research The Influence of Ionizing Radiation on Exosome Composition, Secretion and Intercellular Communication
Protein & Peptide Letters