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Current Psychopharmacology

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ISSN (Print): 2211-5560
ISSN (Online): 2211-5579

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Treating Depression and other Serotonin Deficiency Brain Disorders with Tryptophan

Author(s): Darakhshan Jabeen Haleem*

Volume 11, Issue 1, 2022

Published on: 28 December, 2021

Article ID: e021221198488 Pages: 4

DOI: 10.2174/2211556010666211202104548

Abstract

A deficit in brain serotonin (5-hydroxytryptamine; 5-HT) is implicated in a number of psychiatric illnesses, including depression. The treatment efficacy of this highly prevalent brain disorder is not adequate largely due to the depletion of serotonin stores. Tryptophan, an essential amino acid, is the sole precursor of serotonin; its systemic or oral administration increases serotonin synthesis because tryptophan hydroxylase, the rate-limiting enzyme of 5-HT biosynthesis, is physiologically unsaturated with its substrate. The present article targets the importance of tryptophan supplementation in treating serotonin deficiency and improving therapeutic intervention for depression and other serotonin deficiency brain disorders.

Keywords: Tryptophan, serotonin, depression, tryptophan hydroxylase, antidepressants, biosynthesis.

Graphical Abstract

[1]
Waraich P, Goldner EM, Somers JM, Hsu L. Prevalence and incidence studies of mood disorders: a systematic review of the literature. Can J Psychiatry 2004; 49(2): 124-38.
[http://dx.doi.org/10.1177/070674370404900208] [PMID: 15065747]
[2]
Haleem DJ. Drug targets for obesity and depression: from serotonin to leptin. Curr Drug Targets 2016; 17(11): 1282-91.
[http://dx.doi.org/10.2174/1389450117666151209123049] [PMID: 26648065]
[3]
Blier P. The well of novel antidepressants: running dry. J Psychiatry Neurosci 2010; 35(4): 219-20.
[http://dx.doi.org/10.1503/jpn.100098] [PMID: 20569647]
[4]
Jabeen Haleem D. Raphe-hippocampal serotonin neurotransmission in the sex related differences of adaptation to stress: Focus on serotonin-1A receptor. Curr Neuropharmacol 2011; 9(3): 512-21.
[http://dx.doi.org/10.2174/157015911796558019] [PMID: 22379463]
[5]
Haleem DJ. Targeting serotonin1a receptors for treating chronic pain and depression. Curr Neuropharmacol 2019; 17(12): 1098-108.
[http://dx.doi.org/10.2174/1570159X17666190811161807] [PMID: 31418663]
[6]
Kondaurova EM, Rodnyy AY, Ilchibaeva TV, et al. Genetic background underlying 5-ht1a receptor functioning affects the response to fluoxetine. Int J Mol Sci 2020; 21(22): 8784.
[http://dx.doi.org/10.3390/ijms21228784] [PMID: 33233644]
[7]
Haleem DJ. Improving therapeutics in anorexia nervosa with tryptophan. Life Sci 2017; 178: 87-93.
[http://dx.doi.org/10.1016/j.lfs.2017.04.015] [PMID: 28438641]
[8]
Haleem DJ, Jabeen B, Parveen T. Inhibition of restraint-induced anorexia by injected tryptophan. Life Sci 1998; 63(14): PL205-12.
[http://dx.doi.org/10.1016/S0024-3205(98)00391-9] [PMID: 9771918]
[9]
Hansen F, de Oliveira DL, Amaral FU, et al. Effects of chronic administration of tryptophan with or without concomitant fluoxetine in depression-related and anxiety-like behaviors on adult rat. Neurosci Lett 2011; 499(2): 59-63.
[http://dx.doi.org/10.1016/j.neulet.2011.05.032] [PMID: 21640158]
[10]
Strasser B, Gostner JM, Fuchs D. Mood, food, and cognition: role of tryptophan and serotonin. Curr Opin Clin Nutr Metab Care 2016; 19(1): 55-61.
[http://dx.doi.org/10.1097/MCO.0000000000000237] [PMID: 26560523]
[11]
Haleem DJ. Exaggerated feedback control decreases brain serotonin concentration and elicits hyperactivity in a rat model of diet-restriction-induced anorexia nervosa. Appetite 2009; 52(1): 44-50.
[http://dx.doi.org/10.1016/j.appet.2008.07.009] [PMID: 18721836]
[12]
Moreno FA, Parkinson D, Palmer C, et al. CSF neurochemicals during tryptophan depletion in individuals with remitted depression and healthy controls. Eur Neuropsychopharmacol 2010; 20(1): 18-24.
[http://dx.doi.org/10.1016/j.euroneuro.2009.10.003] [PMID: 19896342]
[13]
Mace JL, Porter RJ, Dalrymple-Alford JC, Wesnes KA, Anderson TJ. The effects of acute tryptophan depletion on neuropsychological function, mood and movement in the healthy elderly. J Psychopharmacol 2011; 25(10): 1337-43.
[http://dx.doi.org/10.1177/0269881110389094] [PMID: 21262857]
[14]
Booij L, van der Does AJW, Haffmans PM, Spinhoven P, McNally RJ. Acute tryptophan depletion as a model of depressive relapse: behavioural specificity and ethical considerations. Br J Psychiatry 2005; 187: 148-54.
[http://dx.doi.org/10.1192/bjp.187.2.148] [PMID: 16055826]
[15]
Delgado PL. Monoamine depletion studies: implications for antidepressant discontinuation syndrome. J Clin Psychiatry 2006; 67(Suppl. 4): 22-6.
[PMID: 16683859]
[16]
Haleem DJ. Glucocorticoids in the physiological and transcriptional regulation of 5-HT1A receptor and the pathogenesis of depression. Neuroscientist 2020; 2020: 1073858420975711.
[http://dx.doi.org/10.1177/1073858420975711] [PMID: 33243080]
[17]
Strasser B, Fuchs D. Diet versus exercise in weight loss and maintenance: focus on tryptophan. Int J Tryptophan Res 2016; 9: 9-16.
[http://dx.doi.org/10.4137/IJTR.S33385] [PMID: 27199566]
[18]
Strasser B, Berger K, Fuchs D. Effects of a caloric restriction weight loss diet on tryptophan metabolism and inflammatory biomarkers in overweight adults. Eur J Nutr 2015; 54(1): 101-7.
[http://dx.doi.org/10.1007/s00394-014-0690-3] [PMID: 24687684]
[19]
Tsujita N, Akamatsu Y, Nishida MM, Hayashi T, Moritani T. Effect of tryptophan, vitamin B6, and nicotinamide-containing supplement loading between meals on mood and autonomic nervous system activity in young adults with subclinical depression: a randomized, double-blind, and placebo-controlled study. Nutr Sci Vitaminol (Tokyo) 2019; 65(6): 507-14.
[http://dx.doi.org/10.3177/jnsv.65.507] [PMID: 31902864]
[20]
Kikuchi AM, Tanabe A, Iwahori Y. A systematic review of the effect of L-tryptophan supplementation on mood and emotional functioning. J Diet Suppl 2021; 18(3): 316-33.
[http://dx.doi.org/10.1080/19390211.2020.1746725] [PMID: 32272859]

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