Recent Advances in Microwave-Assisted Synthesis and Functionalization of 1,2,3- and 1,2,4-triazoles

Title:Recent Advances in Microwave-Assisted Synthesis and Functionalization of 1,2,3- and 1,2,4-triazoles

Volume: 25 Issue: 23

Author(s): Daiana Portella Franco, Lucas Caruso, Nathalia Fonseca Nadur, Thiago Moreira Pereira, Renata Barbosa Lacerda and Arthur Eugen Kümmerle*

Affiliation:

• Laboratorio de Diversidade Molecular e Quimica Medicinal (LaDMol-QM, Molecular Diversity and Medicinal Chemistry Laboratory), Chemistry Institute, Rural Federal University of Rio de Janeiro, Seropedica, 23897-000, Rio de Janeiro,Brazil

Keywords: 1, 2, 3-triazoles, 1, 2, 4-triazoles, microwave-assisted synthesis, heterocycles, classical heating methods, microwave irradiation.

Abstract: Triazoles are five-membered aromatic heterocyclics, which exhibit two isosteric forms (1,2,3-triazoles and 1,2,4-triazoles), as well as multiple applications in medicinal, agricultural, supramolecular, and materials sciences. Famous examples of triazoles include drugs, such as fluconazole, ribavirin, cefatrizine, and tazobactam, as well as herbicides, such as cafenstrole and metosulam. This review aims to present the recent major examples of the application of microwave-assisted organic synthesis (MAOS) to the syntheses and endfunctionalizations of 1,4- and 1,5-disubstituted 1,2,3-triazoles, 1,2,4-triazoles, 3-amino-1,2,4- triazoles, 1,2,4-triazol-3-one, and 1,2,4-triazol-3-thiol derivatives. Notably, the previous reviews on triazole syntheses have not exclusively elucidated the relevance of MAOS techniques in the obtention and derivatization of these compounds.

Cite this article as:

Franco Portella Daiana, Caruso Lucas , Nadur Fonseca Nathalia , Pereira Moreira Thiago, Lacerda Barbosa Renata and Kümmerle Eugen Arthur *, Recent Advances in Microwave-Assisted Synthesis and Functionalization of 1,2,3- and 1,2,4-triazoles, Current Organic Chemistry 2021; 25 (23) . https://dx.doi.org/10.2174/1385272825666211011111408