Recent Advances on Synthesis of 1,4-Benzoxazines and its Derivatives

Title:Recent Advances on Synthesis of 1,4-Benzoxazines and its Derivatives

Volume: 25 Issue: 23

Author(s): Wei Liang, Li-Jing Min, Liang Han and Xing-Hai Liu*

Affiliation:

• College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, 310014, Zhejiang,China

Keywords: 1, 4-benzoxazines, derivatives, heterocyclic compounds, application, synthesis methods, reaction mechanisms.

Abstract: 1,4-benzoxazine compounds are an important class of heterocyclic compounds. Ever since 1,4-benzoxazine was discovered in 1959, it has attracted chemists due to its unique physiological activities, and their synthesis and application have been studied. However, the traditional synthesis methods of 1,4-benzoxazines have some drawbacks, such as complicated steps, harsh reaction conditions and low yield. Therefore, it is still a significant direction to develop new and efficient synthesis methods. In this paper, the synthesis methods and reaction mechanisms of these compounds are reviewed, and the application prospect of 1,4- benzoxazine and its derivatives as a dominant active structure in the future is discussed.

Cite this article as:

Liang Wei , Min Li-Jing , Han Liang and Liu Xing-Hai *, Recent Advances on Synthesis of 1,4-Benzoxazines and its Derivatives, Current Organic Chemistry 2021; 25 (23) . https://dx.doi.org/10.2174/1385272825666211117154031