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Infectious Disorders - Drug Targets

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ISSN (Print): 1871-5265
ISSN (Online): 2212-3989

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Systematic Review Article

Chlamydia pneumoniae and Mycoplasma pneumoniae as Two Emerging Risk Factors in Atherosclerosis: Meta-Analysis Study and Systematic Review

Author(s): Mahsa Jalili , Hassan Nourmohammadi and Kourosh Sayehmiri *

Volume 22, Issue 1, 2022

Published on: 21 September, 2021

Article ID: e210921196697 Pages: 10

DOI: 10.2174/1871526521666210921121423

Price: $65

Abstract

Background: Previous studies suggested an association between Chlamydia pneumoniae and Mycoplasma pneumonia with atherosclerosis, separately. Until now, according to inconsistent information, the relationship between C.pneumoniae and M.pneumoniae with atherosclerosis is controversial.

Objective: The aim of this study is to investigate the association between C.pneumoniae and M.pneumoniae as two separate risk factors with atherosclerosis through systematic review and metaanalysis study.

Methods: We searched databases, such as Pubmed, SID, Magiran, Google scholar and Iranmedex, using the following keywords in English and Persian language: C. pneumoniae, M. pneumoniae, and atherosclerosis. Data were analyzed with meta-analysis and a random effect model. Also, in this study, heterogeneity of articles was estimated by using the I2 index. Finally, the data were analyzed with STAT (version 11.2).

Results: Among thirty-eight articles for C. pneumoniae and five articles for M. pneumoniae individually reviewed that included 2980 samples for M. pneumoniae and 23298 samples for C. pneumoniae, the result demonstrated that the association between M. pneumoniae and C. pneumoniae with atherosclerosis is significant with OR (odds ratio) = 1.58 (95% Confidence Interval (CI): 1.00 to 2.50), OR (odds ratio) = 2.25 (95% Confidence Interval (CI): 1.91 to 2.64), respectively.

Conclusion: This systematic review study provides strong evidence for the role of persistent bacterial infections, such as M. pneumoniae and C. pneumoniae, in potential atherosclerosis. Thus, a novel way should be employed for the complete management of bacterial infection.

Keywords: Mycoplasma pneumoniae, Chlamydia pneumoniae, atherosclerosis, odds ratio, bacterial infections, inflammatory disease.

Graphical Abstract

[1]
Thom DH, Wang S-P, Grayston JT, et al. Chlamydia pneumoniae strain TWAR antibody and angiographically demonstrated coronary artery disease.Arteriosclerosis and Thrombosis: A J Vas Biol 1991; 11(3): 547.
[http://dx.doi.org/10.1161/01.ATV.11.3.547]
[2]
Blasi F, Cosentini R, Raccanelli R, et al. A possible association of Chlamydia pneumoniae infection and acute myocardial infarction in patients younger than 65 years of age. Chest 1997; 112(2): 309-12.
[http://dx.doi.org/10.1378/chest.112.2.309] [PMID: 9266862]
[3]
Thomas GN, Scheel O, Koehler AP, Bassett DC, Cheng AF. Respiratory chlamydial infections in a Hong Kong teaching hospital and association with coronary heart disease. Scand J Infect Dis Suppl 1997; 104(104): 30-3.
[PMID: 9259078]
[4]
Kark JD, Leinonen M, Paltiel O, Saikku P. Chlamydia pneumoniae and acute myocardial infarction in Jerusalem. Int J Epidemiol 1997; 26(4): 730-8.
[http://dx.doi.org/10.1093/ije/26.4.730] [PMID: 9279604]
[5]
Gabriel AS, Gnarpe H, Gnarpe J, Hallander H, Nyquist O, Martinsson A. The prevalence of chronic Chlamydia pneumoniae infection as detected by polymerase chain reaction in pharyngeal samples from patients with ischaemic heart disease. Eur Heart J 1998; 19(9): 1321-7.
[http://dx.doi.org/10.1053/euhj.1998.1010] [PMID: 9792256]
[6]
Boman J, Söderberg S, Forsberg J, et al. High prevalence of Chlamydia pneumoniae DNA in peripheral blood mononuclear cells in patients with cardiovascular disease and in middle-aged blood donors. J Infect Dis 1998; 178(1): 274-7.
[http://dx.doi.org/10.1086/517452] [PMID: 9652454]
[7]
Mazzoli S, Tofani N, Fantini A, et al. Chlamydia pneumoniae antibody response in patients with acute myocardial infarction and their follow-up. Am Heart J 1998; 135(1): 15-20.
[http://dx.doi.org/10.1016/S0002-8703(98)70337-0] [PMID: 9453516]
[8]
Cook PJ, Honeybourne D, Lip GY, Beevers DG, Wise R, Davies P. Chlamydia pneumoniae antibody titers are significantly associated with acute stroke and transient cerebral ischemia: the West Birmingham Stroke Project. Stroke 1998; 29(2): 404-10.
[http://dx.doi.org/10.1161/01.STR.29.2.404] [PMID: 9472881]
[9]
Anderson JL, Carlquist JF, Muhlestein JB, Horne BD, Elmer SP. Evaluation of C-reactive protein, an inflammatory marker, and infectious serology as risk factors for coronary artery disease and myocardial infarction. J Am Coll Cardiol 1998; 32(1): 35-41.
[http://dx.doi.org/10.1016/S0735-1097(98)00203-4] [PMID: 9669246]
[10]
Miyashita N, Toyota E, Sawayama T, et al. Association of chronic infection of Chlamydia pneumoniae and coronary heart disease in the Japanese. Intern Med 1998; 37(11): 913-6.
[http://dx.doi.org/10.2169/internalmedicine.37.913] [PMID: 9868950]
[11]
Cellesi C, Sansoni A, Casini S, et al. Chlamydia pneumoniae antibodies and angiographically demonstrated coronary artery disease in a sample population from Italy. Atherosclerosis 1999; 145(1): 81-5.
[http://dx.doi.org/10.1016/S0021-9150(99)00017-9] [PMID: 10428298]
[12]
Shimada K, Mokuno H, Watanabe Y, et al. Association between Chlamydial infection and coronary artery disease. J Cardiol 1999; 34(5): 259-65.
[PMID: 10579134]
[13]
Sessa R, Di Pietro M, Santino I, et al. Chlamydia pneumoniae infection and atherosclerotic coronary disease. Am Heart J 1999; 137(6): 1116-9.
[http://dx.doi.org/10.1016/S0002-8703(99)70371-6] [PMID: 10347340]
[14]
Altman R, Rouvier J, Scazziota A, Absi RS, Gonzalez C. Lack of association between prior infection with Chlamydia pneumoniae and acute or chronic coronary artery disease. Clin Cardiol 1999; 22(2): 85-90.
[http://dx.doi.org/10.1002/clc.4960220206] [PMID: 10068844]
[15]
Korner B, Wittig P. Ruhlmann. Serologischer Nachweis von Chlamydia-pneumoniae-Lipopolysaccharid-Antikorpern bei Atherosklerosemanifestation in unterschiedlichen Gefäßregionen. Vasa 1999; 28(4): 259-63.
[http://dx.doi.org/10.1024/0301-1526.28.4.259] [PMID: 10611843]
[16]
Leowattana W, Mahanonda N, Bhuripunyo K, Leelarasamee A, Pokum S, Suwimol B. The prevalence of Chlamydia pneumoniae antibodies in Thai patients with coronary artery disease. J Med Associat Thailand Chotmaihet Thangphaet 1999; 82(8): 792-7.
[17]
Kaykov E, Abbou B, Friedstrom S, Hermoni D, Roguin N. Chlamydia preumoniae in ischemic heart disease. Isr Med Assoc J 1999; 1(4): 225-7.
[PMID: 10731348]
[18]
Nobel M, De Torrenté A, Péter O, Genné D. No serological evidence of association between chlamydia pneumonia infection and acute coronary heart disease. Scand J Infect Dis 1999; 31(3): 261-4.
[http://dx.doi.org/10.1080/00365549950163545] [PMID: 10482054]
[19]
Kontula K, Vuorio A, Turtola H, Saikku P. Association of seropositivity for Chlamydia pneumoniae and coronary artery disease in heterozygous familial hypercholesterolaemia. Lancet 1999; 354(9172): 46-7.
[http://dx.doi.org/10.1016/S0140-6736(99)01691-8] [PMID: 10406370]
[20]
Espinola-Klein C, Rupprecht HJ, Blankenberg S, et al. Are morphological or functional changes in the carotid artery wall associated with Chlamydia pneumoniae, Helicobacter pylori, cytomegalovirus, or herpes simplex virus infection? Stroke 2000; 31(9): 2127-33.
[http://dx.doi.org/10.1161/01.STR.31.9.2127] [PMID: 10978041]
[21]
Burian K, Kis Z, Virok D, et al. Independent and joint effects of antibodies to human heat-shock protein 60 and Chlamydia pneumoniae infection in the development of coronary atherosclerosis. Circulation 2001; 103(11): 1503-8.
[http://dx.doi.org/10.1161/01.CIR.103.11.1503] [PMID: 11257076]
[22]
Elkind MS, Lin I-F, Grayston JT, Sacco RL. Chlamydia pneumoniae and the risk of first ischemic stroke: The Northern Manhattan Stroke Study. Stroke 2000; 31(7): 1521-5.
[http://dx.doi.org/10.1161/01.STR.31.7.1521] [PMID: 10884447]
[23]
Romeo F, Martuscelli E, Chirieolo G, et al. Seropositivity against Chlamydia pneumoniae in patients with coronary atherosclerosis. Clin Cardiol 2000; 23(5): 327-30.
[http://dx.doi.org/10.1002/clc.4960230504] [PMID: 10803439]
[24]
Glader CA, Boman J, Saikku P, et al. The proatherogenic properties of lipoprotein(a) may be enhanced through the formation of circulating immune complexes containing Chlamydia pneumoniae-specific IgG antibodies. Eur Heart J 2000; 21(8): 639-46.
[http://dx.doi.org/10.1053/euhj.1999.1755] [PMID: 10731401]
[25]
Ammann P, Marschall S, Kraus M, et al. Characteristics and prognosis of myocardial infarction in patients with normal coronary arteries. Chest 2000; 117(2): 333-8.
[http://dx.doi.org/10.1378/chest.117.2.333] [PMID: 10669671]
[26]
Jantos CA, Krombach C, Wuppermann FN, et al. Antibody response to the 60-kDa heat-shock protein of Chlamydia pneumoniae in patients with coronary artery disease. J Infect Dis 2000; 181(5): 1700-5.
[http://dx.doi.org/10.1086/315442] [PMID: 10823771]
[27]
Mendis S, Arseculeratne YM, Withana N, Samitha S. Chlamydia pneumoniae infection and its association with coronary heart disease and cardiovascular risk factors in a sample South Asian population. Int J Cardiol 2001; 79(2-3): 191-6.
[http://dx.doi.org/10.1016/S0167-5273(01)00420-X] [PMID: 11461741]
[28]
Bloemenkamp DG, Mali WP, Tanis BC, et al. Chlamydia pneumoniae, Helicobacter pylori and cytomegalovirus infections and the risk of peripheral arterial disease in young women. Atherosclerosis 2002; 163(1): 149-56.
[http://dx.doi.org/10.1016/S0021-9150(01)00761-4] [PMID: 12048133]
[29]
Shimada K, Daida H, Mokuno H, et al. Association of seropositivity for antibody to Chlamydia-specific lipopolysaccharide and coronary artery disease in Japanese men. Jpn Circ J 2001; 65(3): 182-7.
[http://dx.doi.org/10.1253/jcj.65.182] [PMID: 11266192]
[30]
Kinjo K, Sato H, Sato H, et al. Joint effects of Chlamydia pneumoniae infection and classic coronary risk factors on risk of acute myocardial infarction. Am Heart J 2003; 146(2): 324-30.
[http://dx.doi.org/10.1016/S0002-8703(03)00150-9] [PMID: 12891203]
[31]
Voorend M, Faber CG, van der Ven AJ, Kessels F, Bruggeman CA, Lodder J. Chlamydia pneumoniae is a likely risk factor for ischemic stroke in young patients. J Stroke Cerebrovasc Dis 2004; 13(2): 85-91.
[http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2004.02.003] [PMID: 17903955]
[32]
Piechowski-Jóźwiak B, Mickielewicz A, Gaciong Z, Berent H, Kwieciński H. Elevated levels of anti-Chlamydia pneumoniae IgA and IgG antibodies in young adults with ischemic stroke. Acta Neurol Scand 2007; 116(3): 144-9.
[http://dx.doi.org/10.1111/j.1600-0404.2007.00819.x] [PMID: 17714326]
[33]
Hasan ZN. Association of Chlamydia pneumoniae serology and ischemic stroke. South Med J 2011; 104(5): 319-21.
[http://dx.doi.org/10.1097/SMJ.0b013e3182114954] [PMID: 21606708]
[34]
Rai NK, Choudhary R, Bhatia R, et al. Chlamydia pneumoniae seropositivity in adults with acute ischemic stroke: A case-control study. Ann Indian Acad Neurol 2011; 14(2): 93-7.
[http://dx.doi.org/10.4103/0972-2327.82792] [PMID: 21808469]
[35]
Shrikhande SN, Zodpey SP, Negandhi H. A case-control study examining association between infectious agents and acute myocardial infarction. Indian J Public Health 2014; 58(2): 106-9.
[http://dx.doi.org/10.4103/0019-557X.132285] [PMID: 24820983]
[36]
Zodpey SP, Shrikhande SN, Negandhi HN, Ughade SN, Joshi PP. Risk factors for acute myocardial infarction in central India: A case-control study. Indian J Community Med 2015; 40(1): 19-26.
[http://dx.doi.org/10.4103/0970-0218.149265] [PMID: 25657508]
[37]
Muro S, Tabara Y, Matsumoto H, et al. Relationship among chlamydia and mycoplasma pneumoniae seropositivity, IKZF1 genotype and chronic obstructive pulmonary disease in a general Japanese population: The Nagahama Study. Medicine (Baltimore) 2016; 95(15)e3371
[http://dx.doi.org/10.1097/MD.0000000000003371] [PMID: 27082601]
[38]
El Yazouli L, Criscuolo A, Hejaji H, et al. Molecular characterisation of Chlamydia pneumoniae associated to atherosclerosis. Pathog Dis 2017; 75(4)
[http://dx.doi.org/10.1093/femspd/ftx039] [PMID: 28387800]
[39]
Momiyama Y, Ohmori R, Taniguchi H, Nakamura H, Ohsuzu F. Association of Mycoplasma pneumoniae infection with coronary artery disease and its interaction with chlamydial infection. Atherosclerosis 2004; 176(1): 139-44.
[http://dx.doi.org/10.1016/j.atherosclerosis.2004.04.019] [PMID: 15306186]
[40]
Georges J-L, Rupprecht HJ, Blankenberg S, et al. Impact of pathogen burden in patients with coronary artery disease in relation to systemic inflammation and variation in genes encoding cytokines. Am J Cardiol 2003; 92(5): 515-21.
[http://dx.doi.org/10.1016/S0002-9149(03)00717-3] [PMID: 12943869]
[41]
Espinola-Klein C, Rupprecht HJ, Blankenberg S, et al. Impact of infectious burden on extent and long-term prognosis of atherosclerosis. Circulation 2002; 105(1): 15-21.
[http://dx.doi.org/10.1161/hc0102.101362] [PMID: 11772870]
[42]
Reunanen A, Roivainen M, Kleemola M, et al. Enterovirus, mycoplasma and other infections as predictors for myocardial infarction. J Intern Med 2002; 252(5): 421-9.
[http://dx.doi.org/10.1046/j.1365-2796.2002.01052.x] [PMID: 12528760]
[43]
Pourahmad M, Jahromy AS, Shojaei M. Association of Mycoplasma pneumoniae infection with myocardial infarction. Am J Immunol 2009; 5: 84-8.
[http://dx.doi.org/10.3844/ajisp.2009.84.88]
[44]
Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 2009; 6(7)e1000097
[45]
Peterson J, Welch V, Losos M, Tugwell P. The Newcastle-Ottawa scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. In: Ottawa: Ottawa Hospital Research Institute 2011.
[http://dx.doi.org/10.1136/bmj.39489.470347.AD] [PMID: 18436948]
[46]
Guyatt GH, Oxman AD, Vist GE, et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ 2008; 336(7650): 924-6.
[http://dx.doi.org/10.1371/journal.pmed.1000097] [PMID: 19621072]
[47]
Hamada M, Yasuda K. Semiconductor memory device enabling test of timing standard for strobe signal and data signal with ease, and subsidiary device and testing device thereof. Google Patents 2002.

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