Abstract
In addition to the modification of the lipid profile, most lipid-lowering agents appear to modulate other atherogenic pathways. We summarize the effects of lipid-lowering agents on inflammation, hemostasis and blood pressure. We also discuss the potential contribution of these actions on cardiovascular disease prevention. Most lipid-lowering agents appear to exert anti-inflammatory, antithrombotic and antihypertensive effects. These pleiotropic actions appear to contribute to the reduction in cardiovascular events and deep venous thrombosis during statin treatment. Regarding other lipid-lowering agents, it is unclear whether their effects on inflammation, thrombosis or blood pressure play a role in their antiatherogenic potential.
Keywords: Statins, fibrates, ezetimibe, colesevelam, nicotinic acid, C-reactive protein, fibrinogen, blood pressure, pleiotropic effects.
Current Pharmaceutical Design
Title:Effects of Lipid-Lowering Agents on Inflammation, Haemostasis and Blood Pressure
Volume: 20 Issue: 40
Author(s): Konstantinos Tziomalos, Asterios Karagiannis and Vasilios G. Athyros
Affiliation:
Keywords: Statins, fibrates, ezetimibe, colesevelam, nicotinic acid, C-reactive protein, fibrinogen, blood pressure, pleiotropic effects.
Abstract: In addition to the modification of the lipid profile, most lipid-lowering agents appear to modulate other atherogenic pathways. We summarize the effects of lipid-lowering agents on inflammation, hemostasis and blood pressure. We also discuss the potential contribution of these actions on cardiovascular disease prevention. Most lipid-lowering agents appear to exert anti-inflammatory, antithrombotic and antihypertensive effects. These pleiotropic actions appear to contribute to the reduction in cardiovascular events and deep venous thrombosis during statin treatment. Regarding other lipid-lowering agents, it is unclear whether their effects on inflammation, thrombosis or blood pressure play a role in their antiatherogenic potential.
Export Options
About this article
Cite this article as:
Tziomalos Konstantinos, Karagiannis Asterios and Athyros G. Vasilios, Effects of Lipid-Lowering Agents on Inflammation, Haemostasis and Blood Pressure, Current Pharmaceutical Design 2014; 20 (40) . https://dx.doi.org/10.2174/1381612820666140622201452
DOI https://dx.doi.org/10.2174/1381612820666140622201452 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
<i>Helicobacter Pylori</i> Interacts with Serum Vitamin D to Influence Hypertension
Current Aging Science Microbial Interaction of Periodontopathic Bacterium Porphyromonas gingivalis and HIV-Possible Causal Link of Periodontal Diseases to AIDS Progression-
Current HIV Research Chemistory of Fibrates
Current Chemical Biology Diabetic Retinopathy and Atherosclerosis: is there a Link?
Current Diabetes Reviews Molecular Docking: Challenges, Advances and its Use in Drug Discovery Perspective
Current Drug Targets Editorial (Thematic Issue: Calcium in Heart Disease: The Ubiquitous Ion)
Medicinal Chemistry Trans-Resveratrol: A Magical Elixir of Eternal Youth?
Current Medicinal Chemistry Phycobiliproteins: A Novel Green Tool from Marine Origin Blue-Green Algae and Red Algae
Protein & Peptide Letters Different Lifestyles in Young Women From Urban and Rural Areas May Explain Different Cardiovascular Risk
Vascular Disease Prevention (Discontinued) Prostaglandin J2 Family and the Cardiovascular System
Current Vascular Pharmacology Network Pharmacology of Ayurveda Formulation <i>Triphala</i> with Special Reference to Anti-Cancer Property
Combinatorial Chemistry & High Throughput Screening The Pharmacogenomics “Side-effect” of TP53/EGFR in Non-small Cell Lung Cancer Accompanied with Atorvastatin Therapy: A Functional Network Analysis
Anti-Cancer Agents in Medicinal Chemistry Monoamine Receptors in the Regulation of Feeding Behaviour and Energy Balance
CNS & Neurological Disorders - Drug Targets Value of Carnitine Therapy in Kidney Dialysis Patients and Effects on Cardiac Function from Human and Animal Studies
Current Drug Targets Endothelial Dysfunction in Morbid Obesity
Current Pharmaceutical Design C-Reactive Protein: Interaction with the Vascular Endothelium and Possible Role in Human Atherosclerosis
Current Pharmaceutical Design The Framingham Brain Donation Program: Neuropathology Along the Cognitive Continuum
Current Alzheimer Research Multiple Mechanisms of Cytokine Action in Neurodegenerative and Psychiatric States: Neurochemical and Molecular Substrates
Current Pharmaceutical Design Inflammatory Related Cardiovascular Diseases: From Molecular Mechanisms to Therapeutic Targets
Current Pharmaceutical Design Editorial (Thematic Issue: Angiogenesis in the Development of Cardiovascular Diseases)
Current Angiogenesis (Discontinued)