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Review Article

聚合物-树枝状大分子杂化物作为抗癌剂的载体

卷 23, 期 4, 2022

发表于: 06 September, 2021

页: [373 - 392] 页: 20

弟呕挨: 10.2174/1389450122666210906121803

价格: $65

摘要

近年来，具有自组装成胶束能力的聚合物材料越来越多地被研究用于各个领域，主要是生物医学。胶束形态在药物转运和递送领域是重要且有趣的，因为胶束可以将疏水分子封装在其细胞核中，提高药物的溶解度，在其外层具有活性分子，并且由于它们的纳米尺寸，它们可以利用EPR 作用，延长循环时间，避免肾脏清除。此外，生物活性分子（可以共价连接或通过宿主-宿主相互作用连接），例如药物、生物成像分子、蛋白质、靶向配体、“可交联”分子或对内部或外部刺激敏感的连接，可以掺入其中.受限的多价协同性和修饰树枝状结构的能力为创建和改进胶束超分子领域中使用的两亲物提供了多功能性。正如本综述中所讨论的，研究最多的结构是杂化共聚物，它是由线性聚合物和树枝状聚合物组合而成的。两亲性树枝状大分子胶束在体外和体内试验中均取得了有效且有希望的结果，这鼓励了对其未来在纳米疗法中的应用的研究。

关键词: 抗癌活性、药物递送、聚合物、树枝状大分子、胶束、纳米结构

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