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Review Article

眼病中的眼内外泌体

卷 22, 期 6, 2022

发表于: 01 September, 2021

页: [540 - 548] 页: 9

弟呕挨: 10.2174/1566524021666210901122948

价格: $65

摘要

外泌体是大小为 30-150nm 的纳米级细胞外囊泡，含有许多生物材料，如信使 RNA（mRNA）、微小 RNA（miRNA）、蛋白质和转录因子。它已在所有生物体液中得到鉴定，并被认为是细胞间通讯的重要组成部分。虽然外泌体在癌症中的作用已被深入研究，但我们对其与眼组织相关性的理解才刚刚开始发展。眼内液，包括房水和玻璃体液，在滋养眼组织和排出代谢物方面发挥作用。在病理状态下，眼内外泌体可介导细胞外基质重塑、视网膜炎症、血视网膜屏障功能障碍等病理过程。在此，我们回顾了眼内外泌体在青光眼、老年性黄斑变性、近视和眼部肿瘤等多种眼病研究中的最新进展，并讨论了眼内外泌体如何促进多种眼病的发病机制和进展。

关键词: 外泌体、房水、玻璃体液、青光眼、年龄相关性黄斑变性、细胞外囊泡。

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