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Mini-Review Article

环状 RNA 在肾病中的新作用

卷 23, 期 4, 2022

发表于: 06 August, 2021

页: [330 - 343] 页: 14

弟呕挨: 10.2174/1389450122666210806124425

价格: $65

摘要

背景：已确定环状 RNA（circRNA）与多种人类疾病有关，如癌症、心血管疾病和自身免疫性疾病。近年来，在肾脏病学中，circRNAs在肾脏疾病发生发展中的作用逐渐被认识。 目的：我们更新并描述了肾脏病学中 circRNAs 在肾脏疾病中的现状。我们特别关注 circRNA 在系统性红斑狼疮和狼疮肾炎中的作用和机制。 方法：我们使用关键词 circRNA、肾脏疾病或肾脏疾病或系统性红斑狼疮，总结了最近发表在 PubMed、Web of Science、Scopus、Scielo 数据库上的报告。 结果： circRNA 在某些肾脏疾病中的研究，例如急性肾损伤、局灶节段性肾小球硬化、特发性膜性肾病、IgA 肾病、糖尿病肾病、高血压肾损伤和特定的狼疮肾炎，阐明了 circRNA 的功能和发病机制。迄今为止，circRNA在上述人类肾脏疾病中的作用机制主要集中在海绵化microRNA和调节靶基因表达的作用。此外，已在血液、尿液和肾脏组织样本中检测到 circRNA。这些结果表明，circRNA可以作为诊断和监测肾脏疾病进展的生物标志物。 结论：CircRNAs在肾脏病学中以狼疮性肾炎为主的肾脏疾病的发病机制、诊断和治疗中发挥着重要作用。

关键词: circRNAs、狼疮肾炎、生物标志物、海绵、系统性红斑狼疮、肾脏病学中的肾脏疾病、microRNAs

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