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Mini-Reviews in Medicinal Chemistry

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ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

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Mini-Review Article

Drug Solubilization by Surfactants: Experimental Methods and Theoretical Perspectives

Author(s): Nisar Ahmad Malik*

Volume 22, Issue 4, 2022

Published on: 03 January, 2022

Page: [579 - 585] Pages: 7

DOI: 10.2174/1389557521666210805111425

Price: $65

Abstract

This mini review will give an insight into the need and usefulness of investigating the solubilization of poorly soluble drugs. Commonly used experimental and theoretical models are outlined to study the efficacy of the carrier or excipient for the poorly soluble drugs. Furthermore, the use of surface active agents for drug solubilization is discussed in correlation with the mathematical models suggested from time to time. A few experimental techniques are also discussed which would be very helpful in elucidating the interactions prevailing in the mixed systems of poorly soluble drugs and surface active agents.

Keywords: Solubilization, drug, surfactant, physiochemical properties, theoretical models, thermodynamic parameters, poorly soluble drugs.

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Graphical Abstract

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