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Current Cardiology Reviews

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ISSN (Print): 1573-403X
ISSN (Online): 1875-6557

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Review Article

Beyond Ejection Fraction: Novel Clinical Approaches Towards Sudden Cardiac Death Risk Stratification in Patients with Dilated Cardiomyopathy

Author(s): Issa Pour-Ghaz, Mark Heckle, Ikechukwu Ifedili, Sharif Kayali, Christopher Nance, Rajesh Kabra, Sunil K. Jha, John L. Jefferies and Yehoshua C. Levine*

Volume 18, Issue 2, 2022

Published on: 04 August, 2021

Article ID: e040821195265 Pages: 9

DOI: 10.2174/1573403X17666210804125939

Price: $65

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Abstract

Implantable Cardioverter-Defibrillator (ICD) therapy is indicated for patients at risk for sudden cardiac death due to ventricular tachyarrhythmia. The most commonly used risk stratification algorithms use Left Ventricular Ejection Fraction (LVEF) to determine which patients qualify for ICD therapy, even though LVEF is a better marker of total mortality than ventricular tachyarrhythmias mortality. This review evaluates imaging tools and novel biomarkers proposed for better risk stratifying arrhythmic substrate, thereby identifying optimal ICD therapy candidates.

Keywords: Sudden cardiac death, risk stratification, cardiac MRI, biomarkers, left ventricular ejection fraction, implantable cardioverter defibrillator.

Graphical Abstract

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