摘要
噻吩并 [3,2-d] 嘧啶环框架包含一类重要的杂环化合物,可作为显示不同药理活性的有前途的平台。 对用于医药产品的噻吩并 [3,2-d] 嘧啶核的兴趣使该支架成为有机化学的一个非常有用的构建块。 本综述介绍了噻吩并 [3,2- d] 嘧啶的最新研究,并阐明了它们在抗癌、抗感染、抗惊厥、抗糖尿病、中枢神经系统和骨质疏松症药物发现中的生物学重要性。 噻吩并[3,2-d]嘧啶的专利也被详细阐述为一条有用的信息。 在这里,我们另外关注这个重要环的合成和新的噻吩并 [3,2-d] 嘧啶的发现。
关键词: 生物活性、药物分子、杂环化合物、专利、构效关系 (SAR)、噻吩并[3
图形摘要
Current Drug Targets
Title:Therapeutic Potential, Synthesis, Patent Evaluation and SAR Studies of Thieno[3,2-d]pyrimidine Derivatives: Recent Updates
Volume: 22 Issue: 17
关键词: 生物活性、药物分子、杂环化合物、专利、构效关系 (SAR)、噻吩并[3
摘要: Thieno[3,2-d]pyrimidine ring framework comprises a significant class of heterocyclics that serve as a promising platform showing different pharmacological activities. The interest in thieno[3,2-d]pyrimidine cores for pharmaceutical products makes this scaffold an exceptionally helpful building block for organic chemistry. This review presents current research on thieno[3,2- d]pyrimidines and elucidates their biological importance in anti-cancer, anti-infectious, anticonvulsant, anti-diabetic, CNS, and osteoporosis drug discoveries. Patents on the thieno[3,2- d]pyrimidines are also elaborated as a piece of useful information. Here, we additionally focus on the synthesis of this vital ring and the discovery of new thieno[3,2-d]pyrimidines.
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Cite this article as:
Therapeutic Potential, Synthesis, Patent Evaluation and SAR Studies of Thieno[3,2-d]pyrimidine Derivatives: Recent Updates, Current Drug Targets 2021; 22 (17) . https://dx.doi.org/10.2174/1389450122666210526094047
DOI https://dx.doi.org/10.2174/1389450122666210526094047 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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