Abstract
Huntington’s disease (HD) is a progressive neurodegenerative disorder which deteriorates the physical and mental abilities of the patients. It is an autosomal dominant disorder and is mainly caused by the expansion of a repeating CAG triplet. A number of animal models ranging from worms, fruit flies, mice and rat, pig, sheep and monkeys are available, which have been helpful in understanding various pathways involved during the progression of the disease. Drosophila is one of the most commonly used model organisms for biomedical science, due to low cost maintenance, short life span and easy implications of genetic tools. The present review provides a brief description of HD and the studies carried out for HD to date, taking Drosophila as a model.
Keywords: Huntington's disease, drosophila, modulation, animal model, brain, trinucleotide repeats.
Graphical Abstract
CNS & Neurological Disorders - Drug Targets
Title:Modulation of Huntington’s Disease in Drosophila
Volume: 20 Issue: 10
Author(s): Iqra Subhan and Yasir Hasan Siddique*
Affiliation:
- Department of Zoology, Drosophila Transgenic Laboratory, Section of Genetics, Faculty of Life Sciences, Aligarh Muslim University, Aligarh-202002, Uttar Pradesh,India
Keywords: Huntington's disease, drosophila, modulation, animal model, brain, trinucleotide repeats.
Abstract: Huntington’s disease (HD) is a progressive neurodegenerative disorder which deteriorates the physical and mental abilities of the patients. It is an autosomal dominant disorder and is mainly caused by the expansion of a repeating CAG triplet. A number of animal models ranging from worms, fruit flies, mice and rat, pig, sheep and monkeys are available, which have been helpful in understanding various pathways involved during the progression of the disease. Drosophila is one of the most commonly used model organisms for biomedical science, due to low cost maintenance, short life span and easy implications of genetic tools. The present review provides a brief description of HD and the studies carried out for HD to date, taking Drosophila as a model.
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Cite this article as:
Subhan Iqra and Siddique Hasan Yasir *, Modulation of Huntington’s Disease in Drosophila, CNS & Neurological Disorders - Drug Targets 2021; 20 (10) . https://dx.doi.org/10.2174/1871527320666210412155508
DOI https://dx.doi.org/10.2174/1871527320666210412155508 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
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