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Review Article

帕金森病、多巴胺、天然产物、新兴疗法、神经退行性疾病、α-突触核蛋白。

卷 23, 期 1, 2022

发表于: 12 April, 2021

页: [21 - 32] 页: 12

弟呕挨: 10.2174/1389450122666210412125018

价格: $65

摘要

背景：索拉非尼分子疗法仍然是晚期肝细胞癌的主要治疗手段。尽管如此，治疗效果低下，由于高化疗耐药率，很少有患者获得持久的益处。 目的：首次对有关三磷酸腺苷结合盒 (ABC) 转运蛋白在索拉非尼治疗肝细胞癌中的作用的文献进行综述。 方法：从开始到 2020 年 10 月，对三个在线数据库（PubMed、Web of Science 和 Scopus）进行了搜索。研究选择、分析和数据收集由两位作者独立进行。 结果：搜索产生了 224 个结果； 29人入选。大多数研究是临床前研究，使用 HCC 细胞系；三个使用过的人体样本。研究强调了索拉非尼在降低 ABC 转运蛋白表达方面的作用。相反，它描述了 ABC 转运蛋白，特别是多药耐药蛋白 1 (MDR-1)、多药耐药相关蛋白 1 和 2 (MRP-1 和 MRP-2) 以及 ABC 亚家族 G 成员 2 (ABCG2) 在索拉非尼中的作用药代动力学和药效学，是关键的耐药因素。与调节 ABC 转运蛋白的天然可用或合成化合物的联合治疗可通过增加吸收和细胞内浓度来恢复索拉非尼耐药性。 结论：更深入地了解 ABC 转运蛋白的机制可能为开发肝细胞癌的创新方法提供指导。需要进一步的研究将当前的知识转化为实践，并为个体化治疗铺平道路。

关键词: 索拉非尼，肝细胞癌，耐药性，ABC 转运蛋白，p-糖蛋白，外排泵。

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