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Review Article

动脉粥样硬化中的循环 miRNA：临床生物标志物和早期诊断工具

卷 22, 期 3, 2022

发表于: 15 March, 2021

页: [250 - 262] 页: 13

弟呕挨: 10.2174/1566524021666210315124438

价格: $65

摘要

动脉粥样硬化是一种血管疾病，其特征是动脉变窄并在动脉内形成斑块。每年记录的相关死亡人数为 1750 万，占全球死亡人数的 31%。已经注意到血管纤维化和动脉粥样硬化之间存在关联。动脉壁增厚和管腔直径减小可能导致细胞外基质 (ECM) 的不必要沉积，这些情况有助于许多临床疾病和病理状况的进展，例如动脉粥样硬化。在这里，我们回顾了各种循环 microRNA (miRNA) 在动脉粥样硬化早期诊断中的作用。我们还试图通过不同的技术深入了解循环 miRNA 的优势和验证。我们讨论了不同的循环 miRNA，例如 miR-17、miR-17-5p、miR-29b、miR-30、miR-92a、miR-126、miR-143、miR-145、miR-146a、miR-212 , miR-218, miR-221, miR-222 和 miR-361-5p 作为临床诊断动脉粥样硬化的生物标志物。本综述中富有洞察力的演示将为研究人员和技术开发人员提供更好的机会来了解当前循环 miRNA 的情况，这有助于他们改进当前临床动脉粥样硬化的诊断技术

关键词: 动脉粥样硬化、血管纤维化、循环 miRNA、生物标志物、诊断工具、血液单核细胞

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