Cross Talk between COVID-19 and Breast Cancer

doi:10.2174/1568009621666210216102236
摘要

癌症患者更容易感染 COVID-19；然而，COVID-19 在不同类型癌症中的流行情况仍然不一致且没有定论。在这里，我们描述了乳腺癌和 COVID-19 之间的错综复杂的关系。乳腺癌和 COVID-19 共同参与共病、激素信号通路、性别差异、肾素-血管紧张素系统 (RAS)、血管紧张素转换酶-2 (ACE-2)、跨膜蛋白酶丝氨酸 2 (TMPRSS2) 和二肽基肽酶-IV（DPP-IV）。我们还阐明了 COVID-19 治疗方式对乳腺癌结果的可能影响。简而言之，我们得出结论，与正常人相比，乳腺癌患者更容易感染 COVID-19。女性对 COVID-19 的发生和严重程度更具抵抗力。 ACE2 和 TMPRSS2 的表达增加与 COVID-19 的发生和严重程度相关，但 ACE2 的高表达和 TMPRSS2 的低表达是乳腺癌总体无病生存的预后标志物。用于 COVID-19 治疗的 ACE2 抑制剂和布洛芬疗法可能通过化疗耐药和转移加重乳腺癌患者的临床状况。大多数可用的 COVID-19 治疗方式也被发现对乳腺癌结果产生积极影响。除了临床趋势药物，TMPRSS2抑制剂、雌激素补充剂、雄激素剥夺和DPP-IV抑制剂也可用于治疗感染SARS-CoV-2的乳腺癌患者。然而，药物相互作用表明，一些用于治疗 COVID-19 的药物可能会调节抗癌疗法的药物代谢，从而可能导致药物不良反应事件。
关键词: 细胞因子风暴、ACE-2 受体、糖尿病、乳腺癌、TMPRSS2、DPP-IV。
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图形摘要

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DOI https://dx.doi.org/10.2174/1568009621666210216102236	Print ISSN 1568-0096
Publisher Name Bentham Science Publisher	Online ISSN 1873-5576
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