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Systematic Review Article

基因治疗对阿尔茨海默病认知功能恢复的疗效:系统综述

卷 21, 期 3, 2021

发表于: 20 January, 2021

页: [246 - 257] 页: 12

弟呕挨: 10.2174/1566523221666210120091146

价格: $65

摘要

背景：阿尔茨海默病(AD)是导致痴呆的主要原因，是一种进行性神经再生疾病，其特征是神经原纤维缠结和老年斑的积累。目前还没有治愈的方法;然而，一些治疗方法可以减缓疾病的进展，包括基因治疗，这被研究为治疗AD的巨大潜力。 目的：这篇综述的目的是确定基因治疗对恢复AD认知的有效性。 方法：系统综述采用了截至2020年5月发表在Web of Science、Scopus和Medline/PUBMED数据库上的论文。如果文章是研究基因治疗对AD认知的影响的原创研究，那么它们将被考虑纳入研究。使用动物干预研究的偏倚风险工具(SYRCLE的Rob工具)和Jadad量表对所选研究的方法质量进行评估。 结果：大多数临床前研究在改善小鼠的记忆和学习能力方面取得了积极的结果，这些小鼠接受了基因治疗。另一方面，临床研究尚未得出与用于基因治疗的病毒载体的传递方式有关的结论。 结论：基因治疗在临床前试验中显示了治疗AD的巨大潜力，但由于临床前研究在预测人类治疗效果方面存在局限性，因此对结果的解释应谨慎。

关键词: 痴呆症，治疗，认知，衰老，阿尔茨海默病，遗传

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