Anticancer Natural Products with Collateral Sensitivity: A Review

Title:Anticancer Natural Products with Collateral Sensitivity: A Review

Volume: 21 Issue: 12

Author(s): Jiajun Qian, Jiahua Cui, Shaoshun Li, Jun Chen*Jinping Jia*

Affiliation:

• Department of Dermatology and Dermatologic Surgery, Shanghai Ninth People’s Hospital, Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200011,China

• School of Environmental Science and Engineering, Shanghai Jiaotong University,China

Keywords: Multidrug resistance, collateral sensitivity, molecular mechanism, structure-activity relationships, anticancer

Abstract:

Background: Multidrug resistance (MDR) is the resistance of cancer cells against a variety of currently used antineoplastic agents with diverse structural scaffolds and different anticancer mechanisms. It has been recognized as one of the major impediments to the successful treatment of cancer, leading to the metastasis and relapse of malignant diseases.

Introduction: Collateral sensitivity (CS) is the characteristic of certain chemicals to kill the drugresistant sublines selectively over the parental cell lines from which the resistant cells were generated. The research and development of new drug candidates with collateral sensitivity will be an efficient approach to conquer multidrug resistance in cancer. We aim to provide an update on the discovery of natural products with collateral sensitivity.

Results and Conclusion: The review focused on the characterized anticancer natural products and their derivatives with collateral sensitivity, their working mechanisms, and related structure-activity relationships, emphasizing recently identified CS compounds. According to their structural features, these MDR-targeting compounds were mainly classified into the following categories: flavonoids, terpenoids, stilbenes, alkaloids and quinones. The exploration of molecular mechanisms of collateral sensitivity and structural features of anticancer agents with collateral sensitivity provided an effective approach for the clinic treatment of MDR in cancer.

Cite this article as:

Qian Jiajun , Cui Jiahua , Li Shaoshun, Chen Jun*, Jia Jinping*, Anticancer Natural Products with Collateral Sensitivity: A Review, Mini-Reviews in Medicinal Chemistry 2021; 21 (12) . https://dx.doi.org/10.2174/1389557521666210112141455