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Current Organic Chemistry

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ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

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Mini-Review Article

Recent Advances in the Chemical Synthesis of Marine Acidic Carbohydrates

Author(s): Xinru Li, Depeng Wang, Ping Zhang, Guangli Yu and Chao Cai*

Volume 25, Issue 4, 2021

Published on: 30 December, 2020

Page: [507 - 518] Pages: 12

DOI: 10.2174/1385272824999201230120805

Price: $65

Abstract

The ocean supplies abundant active compounds, including small organic molecules, proteins, lipids, and carbohydrates, with diverse biological functions. The high-value transformation of marine carbohydrates primarily refers to their pharmaceutical, food, and cosmetic applications. However, it is still a big challenge to obtain these marine carbohydrates in well-defined structures. Synthesis is a powerful approach to access marine oligosaccharides, polysaccharide derivatives, and glycomimetics. In this review, we focus on the chemical synthesis of marine acidic carbohydrates with uronic acid building blocks such as alginate, and glycosaminoglycans. Regioselective sulfation using a chemical approach is also highlighted in the synthesis of marine oligosaccharides, as well as the multivalent glycodendrimers and glycopolymers for achieving specific functions. This review summarizes recent advances in the synthesis of marine acidic carbohydrates, as well as their preliminary structure activity relationship (SAR) studies, which establishes a foundation for the development of novel marine carbohydrate-based drugs and functional reagents.

Keywords: Marine carbohydrates, alginate, fucoidan, marine GAGs, glycomimetics, chemical synthesis, oligosaccharides.

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