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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Research Article

格兰杰因果关系和图论指导阿尔茨海默氏病的定向网络缺陷

卷 17, 期 10, 2020

页: [939 - 947] 页: 9

弟呕挨: 10.2174/1567205017666201215140625

价格: $65

摘要

背景：很少有研究研究阿尔茨海默氏病（AD）不同大脑区域之间定向的全脑相互作用。在这里，我们研究了全脑有效连通性，并研究了与AD相关的图形指标。 方法：进行大规模的格兰杰因果关系分析，以探讨AD患者异常的全脑有效连通性。此外，还从有效的连通性网络中计算了包括小世界性，分类性和层次结构在内的图论度量。与健康对照相比，统计分析确定了AD受试者的异常网络特性。 结果：在AD受试者中发现小世界减少，特征路径长度，分解度和等级增加。 结论：这项工作使人们深入了解了AD个体大脑网络的潜在神经病理学机制，例如信息传递效率较低，并且对随机或定向攻击的适应力降低

关键词: 阿尔茨海默氏病，有效的联系，大规模格兰杰因果关系，功能性连接体，分类性，等级制度。

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