Abstract
Background: The development of drug resistance by bacterial strains is a public health issue, being the main cause of the decrease in the effectiveness of numerous antibiotics. In this context, it is essential to find new drugs with better antibacterial activity.
Objective: The authors proposed to cover relevant literature, published following the review article written by Rani et al., illustrating chemical structures and antibacterial activity of some imidazole derivatives.
Method: Approximately 100 scientific articles presenting more than 150 compounds have been reviewed. The most relevant data have been extracted and systematically arranged in figures and tables.
Results: The reviewed studies used a broad number of bacterial strains, however Staphylococcus aureus as Gram-positive, and Escherichia coli as Gram-negative bacterial strains were most frequently used to assess the activity of these compounds.
Conclusion: Some of the compounds showed promising results against both Gram-positive and Gram-negative bacterial strains, thus further analysis should be performed in terms of toxicity, pharmacokinetics and pharmacodynamics. Additional screening of these imidazole derivatives could lead to useful compounds with potential broad-spectrum antibacterial activity against resistant pathogens.
Keywords: Imidazole, Benzimidazole, Antibacterial Activity, Inhibitory Concentration, Structure Activity Relationship, Antibacterial Drug, Staphylococcus aureus, Escherichia coli
Graphical Abstract
Mini-Reviews in Medicinal Chemistry
Title:Imidazole Derivatives and their Antibacterial Activity - A Mini-Review
Volume: 21 Issue: 11
Author(s): Gâz Șerban Andrei*, Boda Francisc Andrei*Pop Rahela Roxana
Affiliation:
- Department of Organic Chemistry, Faculty of Pharmacy, University of Medicine, Pharmacy, Science and Technology “George Emil Palade” of Targu Mures, Targu Mures,Romania
- Department of General and Inorganic Chemistry, Faculty of Pharmacy, University of Medicine, Pharmacy, Science and Technology “George Emil Palade” of Targu Mures, Targu Mures,Romania
Keywords: Imidazole, Benzimidazole, Antibacterial Activity, Inhibitory Concentration, Structure Activity Relationship, Antibacterial Drug, Staphylococcus aureus, Escherichia coli
Abstract:
Background: The development of drug resistance by bacterial strains is a public health issue, being the main cause of the decrease in the effectiveness of numerous antibiotics. In this context, it is essential to find new drugs with better antibacterial activity.
Objective: The authors proposed to cover relevant literature, published following the review article written by Rani et al., illustrating chemical structures and antibacterial activity of some imidazole derivatives.
Method: Approximately 100 scientific articles presenting more than 150 compounds have been reviewed. The most relevant data have been extracted and systematically arranged in figures and tables.
Results: The reviewed studies used a broad number of bacterial strains, however Staphylococcus aureus as Gram-positive, and Escherichia coli as Gram-negative bacterial strains were most frequently used to assess the activity of these compounds.
Conclusion: Some of the compounds showed promising results against both Gram-positive and Gram-negative bacterial strains, thus further analysis should be performed in terms of toxicity, pharmacokinetics and pharmacodynamics. Additional screening of these imidazole derivatives could lead to useful compounds with potential broad-spectrum antibacterial activity against resistant pathogens.
Export Options
About this article
Cite this article as:
Andrei Șerban Gâz *, Andrei Francisc Boda *, Roxana Rahela Pop , Imidazole Derivatives and their Antibacterial Activity - A Mini-Review, Mini-Reviews in Medicinal Chemistry 2021; 21 (11) . https://dx.doi.org/10.2174/1389557520999201209213648
DOI https://dx.doi.org/10.2174/1389557520999201209213648 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
![](/images/wayfinder.jpg)
- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Mechanisms of Drug Hypersensitivity Reactions and the Skin
Recent Patents on Inflammation & Allergy Drug Discovery Contraception in Women with Medical Conditions
Current Women`s Health Reviews Virtual Screening for the Development of New Effective Compounds Against Staphylococcus aureus
Current Medicinal Chemistry Molecular Binding and Simulation Studies of Staphylococcus aureus Superantigens with Flavonoid Compounds
Infectious Disorders - Drug Targets Antimicrobial Peptides as Anti-biofilm Agents in Medical Implants
Current Topics in Medicinal Chemistry Additive Effect of MCP in Combination with Cefotaxime Against Staphylococcus aureus
Medicinal Chemistry Epidemiological Review of Gonococcal Infection
Current Women`s Health Reviews Recent Advances in Natural Product-Based Anti-Biofilm Approaches to Control Infections
Mini-Reviews in Medicinal Chemistry The Family of Serratia Type Pore Forming Toxins
Current Protein & Peptide Science Ethanol and Inflammation
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Elucidating Protein-protein Interactions Through Computational Approaches and Designing Small Molecule Inhibitors Against them for Various Diseases
Current Topics in Medicinal Chemistry Regulating the Safety of Probiotics - The European Approach
Current Pharmaceutical Design Susceptibility of Intracellular Coxiella burnetii to Antimicrobial Peptides in Mouse Fibroblast Cells
Protein & Peptide Letters Staphylococcus aureus: Current State of Prevalence, Impact, and Vaccine Development
Current Pharmaceutical Design Hybrid Drugs as Potential Combatants Against Drug-Resistant Microbes: A Review
Current Topics in Medicinal Chemistry Hybrid Viral Vectors for Vaccine and Antibody Production in Plants
Current Pharmaceutical Design Antimicrobial Drug Interactions in the Critically Ill Patients
Current Clinical Pharmacology Beyond Hemostasis: The Role of Platelets in Inflammation, Malignancy and Infection
Cardiovascular & Hematological Disorders-Drug Targets MRSA Infections: From Classical Treatment to Suicide Drugs
Current Medicinal Chemistry Oral Infection and Vascular Disease
Vascular Disease Prevention (Discontinued)