Hybrid Drugs as Potential Combatants Against Drug-Resistant Microbes: A Review

Title:Hybrid Drugs as Potential Combatants Against Drug-Resistant Microbes: A Review

Volume: 17 Issue: 8

Author(s): Haythem A. Saadeh and Mohammad S. Mubarak

Affiliation:

Keywords: Drug resistant, Hybrids, Bacteria, Malaria, Staphylococcus, Tuberculosis

Abstract: Antimicrobial resistance to drugs is a serious threat to public health. Different strategies have been adopted to deal with antimicrobial resistance to known drugs, one such strategy is the use of drug hybrids; this is a promising strategy to address the growing problem of drug resistance. The present review covers the very recent examples of combining (hybrid) two standard drugs in a single molecule for combating antibiotic-resistant microorganisms, and to present evidence supporting that drug hybrids are the urgent and practical solution to stop or slow down the spread of drug resistance. In addition, this review provides a literature overview of antimicrobial hybrids of standard drugs and their impact on antimicrobial resistance, covering publications between 2015 and 2016.

Cite this article as:

Saadeh A. Haythem and Mubarak S. Mohammad, Hybrid Drugs as Potential Combatants Against Drug-Resistant Microbes: A Review, Current Topics in Medicinal Chemistry 2017; 17 (8) . https://dx.doi.org/10.2174/1568026616666160927155251