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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Mini-Review Article

Recent Applications of Benzimidazole as a Privileged Scaffold in Drug Discovery

Author(s): Yongzhen Guo, Xuben Hou* and Hao Fang*

Volume 21, Issue 11, 2021

Published on: 04 August, 2020

Page: [1367 - 1379] Pages: 13

DOI: 10.2174/1389557520666200804124924

Price: $65

Abstract

Benzimidazole is an aromatic bicyclic heterocycle that is regarded as a valuable privileged scaffold in medicinal chemistry. Many marketed drugs and natural products containing benzimidazole scaffolds exert great influence in fighting various diseases, such as hypertension, peptic ulcers, parasitic infections, and cancer. In this review, we introduce the pharmacological applications of some marketed drugs and lead compounds with a focus on anticancer agents, reporting the corresponding data to show the biological activities at their targets. The publications in this review encompass those from 2014 to 2019.

Keywords: Benzimidazole, privileged scaffold, anti-cancer, pharmacological applications, drug discovery, antiallergic.

Graphical Abstract


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