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Review Article

ACE2、ADAM17、TMPRSS2、雄激素受体等宿主细胞蛋白能否成为 SARS-CoV-2 感染的有效靶点？

卷 22, 期 10, 2021

发表于: 25 November, 2020

页: [1149 - 1157] 页: 9

弟呕挨: 10.2174/1389450121999201125201112

价格: $65

摘要

2019 年 12 月在中国武汉引起大规模疾病暴发的新型 β 冠状病毒，严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV- -2) 目前正在全球蔓延。随着病毒刺突与宿主细胞受体的结合，病毒包膜与宿主细胞膜的融合是成功感染 SARS-CoV-2 的关键步骤。在这个进入过程中，宿主细胞的多种蛋白酶和雄激素受体直接或间接地发挥着非常重要的作用。 SARS-CoV-2 进入的这些特征导致其快速传播和严重症状，感染患者的死亡率很高。本综述基于最新发表的文献，包括综述文章、研究文章、假设手稿、预印本文章和官方文件。文献检索是从与 SARS-CoV 和 SARS-CoV-2 相关的生理方面的各种已发表论文中进行的。在本报告中，我们关注宿主细胞蛋白酶（ACE2、ADAM17、TMPRSS2）和雄激素受体（AR）在 SARS-CoV-2 感染中的作用。我们提出的假设是基于蛋白酶 ACE2、ADAM17、TMPRSS2 和 AR 在 SARS-CoV-2 感染中所起的作用，这是根据各种研究推导出来的。我们还总结了这些宿主蛋白如何增加 SARS-CoV-2 的病理学和感染能力，我们认为它们的抑制可能是预防 SARS-CoV-2 感染的一种治疗选择。

关键词: SARS-CoV-2、COVID-19、ACE2、ADAM17、TMPRSS2、雄激素受体、抗病毒药物。

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