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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Energy Remodeling, Mitochondrial Disorder and Heart Failure

Author(s): Peng Wang, Lei Xu and Aijun Sun

Volume 22, Issue 31, 2016

Page: [4823 - 4829] Pages: 7

DOI: 10.2174/1381612822666160708224330

Price: $65

Abstract

Heart failure (HF) is a major global problem in public health with no curative treatment currently available. Energy remodeling is one of the features in HF, preceding cardiac structure remodeling. As an important energy organelle, mitochondrion plays critical roles in the progress of HF. This review focuses on the potential mechanisms linking mitochondrial functions and energy remodeling in HF including the energy starvation theory and energy substrate metabolism. It also highlights the potentials of novel drugs targeting HF energy metabolism.

Keywords: Energy metabolism, mitochondrial disorder, heart failure.


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