靶向癌症中 NUDIX 家族和 SAMHD1 的核苷酸代谢蛋白

Title:Targeting the Nucleotide Metabolism Proteins of the NUDIX Family and SAMHD1 in Cancer

Volume: 28 Issue: 21

关键词: NUDIX、MTH1、SAMHD1、癌症、治疗、抑制剂。

摘要: Nucleotide metabolism has been targeted for many years and in various clinical settings, including cancer. The increased knowledge of certain enzymes involved in this metabolism and associated cellular processes accumulated over the last few years, gives important information related to the druggability of certain proteins and the use of inhibitors for others. Here, we review recent data on such enzymes with a major interest in drug development, i.e. SAMHD1 and the proteins of the NUDIX family. These include information on their roles in cancer progression, correlations with clinical outcomes in cancer patients, and the development and study of enzymatic inhibitors.

Cite this article as:

Targeting the Nucleotide Metabolism Proteins of the NUDIX Family and SAMHD1 in Cancer, Current Medicinal Chemistry 2021; 28 (21) . https://dx.doi.org/10.2174/0929867328666201125120422