摘要
严重急性呼吸综合征相关冠状病毒2型(新型冠状病毒)是冠状病毒科的一种致病性极强的病毒。2019年12月首次发现于中国武汉,在对一种新出现的不明致病原的肺炎群进行流行病学调查后,3月11日世界卫生组织(世卫组织)发布了新型冠状病毒这种流行病的病因,并指出2019年在110多个国家(新冠肺炎)有超过118000例冠状病毒疾病病例。尽管药物重新定位研究在新冠肺炎治疗中取得了预期的结果,但其安全性和有效性的证据仍不够充足。基于细胞的疗法已被证明在治疗多种肺损伤和疾病中是安全且可能有效的,但其在新冠肺炎治疗中的潜在用途尚未阐明。我们在这篇综述中的目的是概述干细胞及其分泌细胞在治疗包括肺损伤在内的许多疾病中的免疫调节作用和再生能力。这些发现可能有助于更好地理解干细胞疗法在新型冠状病毒感染中的潜力及其潜在用途,以便找到解决这一医疗危机的方法。
关键词: 冠状病毒,新冠肺炎,干细胞,细胞激素风暴,肺损伤,免疫调节作用。
Current Molecular Medicine
Title:Addressing the Importance of Stem Cell-Based Therapy: A Perspective in the Treatment of COVID-19
Volume: 21 Issue: 6
关键词: 冠状病毒,新冠肺炎,干细胞,细胞激素风暴,肺损伤,免疫调节作用。
摘要: Severe acute respiratory syndrome-associated coronavirus 2 (SARS-CoV-2) is an extremely pathogenic virus belonging to the family of Coronaviridae. First identified in Wuhan, China in December 2019 after an epidemiological investigation of an emerging cluster of pneumonia of unknown etiology, SARS-CoV-2 was declared the cause of a pandemic on March 11 by the World Health Organization (WHO), pointing to the over 118000 cases of Coronavirus disease 2019 (COVID-19) in over 110 countries. Despite the promising results of drug repositioning studies in the treatment of COVID-19, the evidence of their safety and efficacy remains inconclusive. Cell based therapy has been proven safe and possibly effective in treating multiple lung injuries and diseases, but its potential use in the treatment of COVID-19 has not been yet elucidated. Our aim in this review is to provide an overview of the immunomodulatory effect and the regenerative capacity of stem cells and their secretome in the treatment of many diseases including lung injuries. Those findings may contribute to a better understanding of the potential of stem cell therapy in SARS-CoV-2 infection and its potential use in order to find a solution for this healthcare crisis.
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Cite this article as:
Addressing the Importance of Stem Cell-Based Therapy: A Perspective in the Treatment of COVID-19, Current Molecular Medicine 2021; 21 (6) . https://dx.doi.org/10.2174/1566524020999201117120147
DOI https://dx.doi.org/10.2174/1566524020999201117120147 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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