Abstract
The pandemic of coronavirus disease 2019 (COVID-19) has become a threat to human life and society. Scientists and clinicians are struggling with the intrusive SARS-CoV-2 virus to enhance their knowledge about its pathogenesis and find an effective medicine and vaccine to combat its complications. Till now, they have learned that this SARS-CoV-2 has not infected all people exposed to this virus, and also severe respiratory illnesses have not been observed in all infected patients. Patients over 65 or with underlying diseases are more vulnerable to develop severe disease. Based on this premise, a highly challenging question is why some people are more susceptible to this virus and others are not. The present study was aimed to review the current information, which explains the broad spectrum of COVID-19 presentation. Here, we discussed how genetic background, immune system, underlying disease, smoking status, as well as age, race, and gender affect COVID-19 susceptibility.
Keywords: COVID-19, SARS-CoV-2, Age, Race, Gender, Smoking status, Genetic susceptibility, Immune system, Underlying diseases.
Current Molecular Medicine
Title:Do Genetic Factors Predispose People to COVID-19: A Review Article
Volume: 21 Issue: 6
Author(s): Ava Nasrolahi, Karimeh Haghani, Ali Gheysarzadeh and Salar Bakhtiyari*
Affiliation:
- Department of Clinical Biochemistry, School of Medicine, Ilam University of Medical Sciences, Ilam,Iran
Keywords: COVID-19, SARS-CoV-2, Age, Race, Gender, Smoking status, Genetic susceptibility, Immune system, Underlying diseases.
Abstract: The pandemic of coronavirus disease 2019 (COVID-19) has become a threat to human life and society. Scientists and clinicians are struggling with the intrusive SARS-CoV-2 virus to enhance their knowledge about its pathogenesis and find an effective medicine and vaccine to combat its complications. Till now, they have learned that this SARS-CoV-2 has not infected all people exposed to this virus, and also severe respiratory illnesses have not been observed in all infected patients. Patients over 65 or with underlying diseases are more vulnerable to develop severe disease. Based on this premise, a highly challenging question is why some people are more susceptible to this virus and others are not. The present study was aimed to review the current information, which explains the broad spectrum of COVID-19 presentation. Here, we discussed how genetic background, immune system, underlying disease, smoking status, as well as age, race, and gender affect COVID-19 susceptibility.
Export Options
About this article
Cite this article as:
Nasrolahi Ava , Haghani Karimeh , Gheysarzadeh Ali and Bakhtiyari Salar *, Do Genetic Factors Predispose People to COVID-19: A Review Article, Current Molecular Medicine 2021; 21 (6) . https://dx.doi.org/10.2174/1566524020999201113102145
DOI https://dx.doi.org/10.2174/1566524020999201113102145 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Synthesis, Structure-Activity Relationships and Biological Activity of New Isatin Derivatives as Tyrosinase Inhibitors
Current Topics in Medicinal Chemistry Targeting Host Cell Proteases to Prevent SARS-CoV-2 Invasion
Current Drug Targets COVID-19 and Pneumolysis Simulating Extreme High-altitude Exposure with Altered Oxygen Transport Physiology; Multiple Diseases, and Scarce Need of Ventilators: Andean Condor's-eye-view
Reviews on Recent Clinical Trials COVID-19 and Comorbidities: Is Inflammation the Underlying Condition in Children? A Narrative Review
Current Pediatric Reviews The Two fACEs of the Tissue Renin-Angiotensin Systems: Implication in Cardiovascular Diseases
Current Pharmaceutical Design Predicting Protein-Ligand Binding Sites Based on an Improved Geometric Algorithm
Protein & Peptide Letters Effectiveness of a Lockdown Policy During a Global Pandemic
Current Chinese Science Doctoral Degree Surplus and Dwindling Quality: A Perilous Blend for Young Scientists in Tackling COVID-19 Like Pandemics
Combinatorial Chemistry & High Throughput Screening Natural Agents Modulating ACE-2: A Review of Compounds with Potential against SARS-CoV-2 Infections
Current Pharmaceutical Design Prediction of Infection and Death Ratio of COVID-19 Virus in Turkey by Using Artificial Neural Network (ANN)
Coronaviruses Potential Immunotherapy against SARS-CoV-2: Strategy and Status
Coronaviruses Postpartum Posterior Reversible Encephalopathy Syndrome in a Patient Suspected to COVID-19
Anti-Infective Agents Recent Advances in Targeting Viral Proteases for the Discovery of Novel Antivirals
Current Topics in Medicinal Chemistry COVID-19 and Domestic Animals: Exploring the Species Barrier Crossing, Zoonotic and Reverse Zoonotic Transmission of SARS-CoV-2
Current Pharmaceutical Design Withdrawal Notice: Update on the SARS-CoV-2 (COVID-19) Outbreak: A Global Pandemic Challenge
Coronaviruses Recent Developments in Lipid Drugs
Mini-Reviews in Medicinal Chemistry Effect of the Phytochemical Agents against the SARS-CoV and Some of them Selected for Application to COVID-19: A Mini-Review
Current Pharmaceutical Biotechnology Cardiac Complications Attributed to Hydroxychloroquine: A Systematic Review of the Literature Pre-COVID-19
Current Cardiology Reviews Regenerative Medicine Approaches in COVID-19 Pneumonia
Current Stem Cell Research & Therapy Can Probiotics Cure Inflammatory Bowel Diseases?
Current Pharmaceutical Design