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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Review Article

LncRNA Xist，X染色体不稳定和阿尔茨海默氏病

卷 17, 期 6, 2020

页: [499 - 507] 页: 9

弟呕挨: 10.2174/1567205017666200807185624

价格: $65

摘要

在全球范围内，神经退行性疾病（NDD）是导致与年龄相关的精神残疾的主要原因。大多数NDD像阿尔茨海默氏病（AD）一样，本质上都很复杂-意味着它们在异质性临床结果和潜在分子范例而言，它们都是多参数的。高通量基因组，转录组和小RNA测序实验的新证据提示，长非编码RNA（lncRNA）在AD中的作用。 X灭活特异性转录本（XIST）是Xic（X染色体失活中心）的组成部分，是胎盘哺乳动物X染色体上X灭活过程必不可少的RNA基因。大量的文献调查表明，Xist表达的异常，在某些情况下，X染色体失活的整体破坏在AD中起重要作用。考虑到Xist作为内源性沉默分子的巨大潜力，使用Xist作为非常规染色体沉默剂来治疗具有染色体改变的疾病的想法也正在实施。关于Xist如何在AD中扮演这样的角色的全面知识仍然难以捉摸。在这篇综述中，我们从控制NDD的分子机制的角度，主要集中于阿尔茨海默氏病，整理了有关Xist参与和放松管制的现有知识。还讨论了XIST介导的治疗干预的可能性以及XIC与女性对AD的易感性之间的联系。

关键词: 阿尔茨海默氏病，长非编码RNA，X染色体不稳定，Xist，神经退行性疾病，亨廷顿舞蹈病。

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