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General Review Article

Precision Medicine in the Renin-Angiotensin System: Therapeutic Targets and Biological Variability

Author(s): Guillermo Alberto Keller*, Maria Laura Ferreiros-Gago, Hector Di-Salvo and Guillermo Di Girolamo

Volume 21, Issue 15, 2020

Page: [1625 - 1637] Pages: 13

DOI: 10.2174/1389450121666200719010849

Price: $65

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Abstract

Pathologies linked to the renin-angiotensin system are frequent, and the drugs used in them are numerous and show great variability in therapeutic effects and adverse reactions. Genetic variants have been detected in the angiotensinogen gene (6), angiotensin-converting enzyme (9), angiotensinconverting enzyme 2 (1), and angiotensin receptor Type 1 (4) among others. However, the large number of studies that have analyzed each of them makes it complex and almost impossible to consider all the existing information. This manuscript aims to review the effects of the different known variants on the expected response of different drugs as a basis for the future development of therapeutic guidelines that seek to implement therapeutic individualization strategies on the renin-angiotensin system.

Keywords: Precision medicine, renin-angiotensin-aldosterone system, aldosterone, population biological variations, angiotensinogen gene, angiotensin receptor.

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