Lower Uric Acid Linked with Cognitive Dysfunction in the Elderly

Title:Lower Uric Acid Linked with Cognitive Dysfunction in the Elderly

Volume: 14 Issue: 5

Author(s): Edna Mendez-Hernandez, Jose Salas-Pacheco, Luis Ruano-Calderon, Alfredo Tellez-Valencia, Jorge Cisneros-Martinez, Marcelo Barraza-Salas and Oscar Arias-Carrion

Affiliation:

Keywords: Cardiovascular risk factors, cognitive dysfunction, dementia, elderly, serum uric acid.

Abstract: Uric acid has been associated as a risk factor for cardiovascular disease. Recently, however, there is growing evidence that uric acid plays a role as antioxidant in the brain. In cognitive dysfunction, vascular and oxidative stress mechanisms play a role, but the link remains unknown. Therefore, we investigated the link between serum uric acid-levels and cognitive function in 62 elderly subjects. The statistical analysis was adjusted to age, sex and cardiovascular risk factors. Here, we found that lower serum uric acid levels are linked to cognitive dysfunction. In a Mexican population, higher levels of uric acid are associated with a decreased risk of dementia.

Cite this article as:

Mendez-Hernandez Edna, Salas-Pacheco Jose, Ruano-Calderon Luis, Tellez-Valencia Alfredo, Cisneros-Martinez Jorge, Barraza-Salas Marcelo and Arias-Carrion Oscar, Lower Uric Acid Linked with Cognitive Dysfunction in the Elderly, CNS & Neurological Disorders - Drug Targets 2015; 14 (5) . https://dx.doi.org/10.2174/1871527314666150430161659