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Review Article

综述：CD24在肿瘤诊断、进展和治疗中的作用

卷 20, 期 2, 2020

页: [109 - 126] 页: 18

弟呕挨: 10.2174/1566523220666200623170738

价格: $65

摘要

CD24是一种黏液样GPI-锚定分子。通过免疫组织化学的方法，在许多实体肿瘤中广泛发现，如乳腺癌、生殖系统肿瘤、消化系统肿瘤、神经系统肿瘤等。CD24的功能作用要么通过与配体结合来实现，要么参与信号转导，介导肿瘤的开始和进展。然而，CD24的特性仍然是有趣的，因为关于CD24对肿瘤的影响仍然有反对的声音。在临床前研究中，CD24靶向治疗，包括单克隆抗体、RNA干扰的靶沉默和免疫治疗，为我们的抗肿瘤应用显示了光明的前景。然而，迫切需要基于临床研究的证据。在此，我们从肿瘤的角度对有关CD24的相关研究进行总结，以期激发新的观点。

关键词: CD24，癌症，单克隆抗体，免疫治疗，淋巴细胞，粒细胞

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