DNA Methylation Biomarkers in Serum for Gastric Cancer Screening

Title: DNA Methylation Biomarkers in Serum for Gastric Cancer Screening

Volume: 10 Issue: 11

Author(s): Ting Ye, Yingxuan Chen and Jingyuan Fang

Affiliation:

Keywords: DNA methylation, biomarker, serum, gastric cancer, proto-oncogene, tumor suppressor gene, Relapse, Serum-based detection, Non-invasive monitoring, Transcriptional regulation, Proto-oncogenes, Cell cycle regulator genes, Gastric carcinogenesis, Neuroblastoma, Colorectal cancers, Epigenetic alterations, DAP-kinase, Survival prediction

Abstract: Epigenetic alterations occur throughout the development and carcinogenesis of gastric cancer. Therefore, the detection of methylated DNA markers is predicted to be able to detect gastric cancer earlier, and improve the risk assessment, surveillance, relapse, and prognosis of patients with gastric cancer. Detection of free methylated DNA also represents a promising approach for developing serum-based detection methods for the non-invasive monitoring of gastric cancer progression.

Cite this article as:

Ye Ting, Chen Yingxuan and Fang Jingyuan, DNA Methylation Biomarkers in Serum for Gastric Cancer Screening, Mini-Reviews in Medicinal Chemistry 2010; 10 (11) . https://dx.doi.org/10.2174/1389557511009011034