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Review Article

事实与误区：换用氯喹和羟氯喹治疗COVID-19的功效

卷 21, 期 16, 2020

页: [1703 - 1721] 页: 19

弟呕挨: 10.2174/1389450121666200617133142

价格: $65

摘要

2019年冠状病毒疾病（COVID-19）的出现是由2019年新型冠状病毒（2019-nCoV）引起的。 2019-nCoV首先在武汉爆发，由于其极高的传输效率而随后在世界范围内传播。全球已报告了COVID-19的病例和死亡，世界卫生组织已宣布这一暴发为大流行，国际卫生当局已将重点放在对患者的快速诊断和隔离以及寻找能够抵抗疾病严重程度的疗法上。由于缺乏已知的具体，有效和经过验证的疗法以及公共卫生紧急情况的发生，药物再利用似乎是找到针对2019-nCoV感染的治疗解决方案的最佳方法。重新使用抗疟药和氯喹（CQ）/羟氯喹（HCQ）已显示出抑制大多数冠状病毒（包括SARS-CoV-1冠状病毒）的功效。这些CQ类似物已显示出在体外抑制2019-nCoV的潜在功效，从而引起了一些未来的临床试验的关注。这篇综述讨论了CQ类似物可能干扰2019-nCoV复制周期和感染的有效作用和机制。

关键词: 2019-nCoV，COVID-19，药物再利用，羟氯喹，临床试验，大流行。

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