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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Review Article

卵巢癌的战略联合治疗

卷 20, 期 8, 2020

页: [573 - 585] 页: 13

弟呕挨: 10.2174/1568009620666200511084007

价格: $65

摘要

卵巢癌仍然是全世界女性与妇科癌症相关死亡的主要原因。 糟糕的生存率部分归因于标准化的减体手术和一线化疗后的复发。 近年来，靶向疗法，包括抗血管生成剂或聚（ADP-核糖）聚合酶抑制剂，代表了卵巢癌治疗的突破。 随着对卵巢癌生物学的更深入了解补充了更多的治疗剂，正在积极研究一系列联合治疗方法，以进一步改善该疾病的临床结果。 这些组合涉及DNA损伤剂，信号传导途径的靶向疗法和免疫疗法，同时靶向多种癌症途径或标志，以诱导累加或协同的抗肿瘤活性。 在这里，我们回顾了开发有效的联合疗法治疗卵巢癌的临床前数据和正在进行的临床试验。 这些新兴的治疗方式可能会重塑该疾病的治疗格局。

关键词: 化学疗法，联合疗法，免疫疗法，卵巢癌，靶向疗法，聚（ADP-核糖）聚合酶抑制剂。

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