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Meta-Analysis

大肠癌蛋白质组学血液标记物的meta分析

卷 28, 期 6, 2021

发表于: 27 April, 2020

页: [1176 - 1196] 页: 21

弟呕挨: 10.2174/0929867327666200427094054

价格: $65

摘要

背景：早期诊断可显著提高结直肠癌(CRC)生存率;然而，现有的CRC筛查方法要么是侵入性的，要么是低效的。在CRC早期诊断中迫切需要新的标记物。血清蛋白质组学在发现新的标志物、提供反映癌症早期和预测CRC预后的标志物方面具有巨大潜力。本文通过meta分析对CRC研究的蛋白质组学结果进行总结，以获得新标记物的诊断效率。 方法：对文献数据库进行系统检索，收集应用蛋白质组学方法探索血液结直肠癌标志物的研究。评估这些研究中的检测和验证方法，以及生物标志物的特异性和敏感性。纳入研究的质量评估采用纽卡斯尔-渥太华量表(NOS)病例对照研究版本。 结果：从751项研究中筛选出34项研究，总结了蛋白质组学检测的标志物。根据其生物学功能，共有59种蛋白质被分类。这些标记物的敏感性、特异性或AUC各不相同。其中，哺乳动物ste20样蛋白激酶1/丝氨酸苏氨酸激酶4 (MST1/STK4)、S100钙结合蛋白A9 (S100A9)和金属蛋白酶组织抑制剂1 (TIMP1)适合进行效应大小合并，合并后重新计算它们的诊断效率。MST1/STK4的敏感性为68%，特异性为78%。S100A9的灵敏度为72%，特异性为83%，AUC为0.88。TIMP1的灵敏度为42%，特异性为88%，AUC为0.71。 结论：MST1/STK4、S100A9和TIMP1在CRC检测中表现出了优异的性能。其他几个标记物对于CRC早期检测也有较好的诊断效果，但在适合临床使用前还需要进一步验证。发现更有效的标记物将有利于结直肠癌的治疗。

关键词: CRC，蛋白质组学，早期诊断，血液标志物，诊断，早期检测

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