Healthy Gut, Healthy Brain: The Gut Microbiome in Neurodegenerative Disorders

Mulak, A.; Bonaz, B. Brain-gut-microbiota axis in Parkinson’s disease. World J. Gastroenterol., 2015, 21(37), 10609-10620.
[http://dx.doi.org/10.3748/wjg.v21.i37.10609] [PMID: 26457021]

Houser, M.C.; Tansey, M.G. The Gut-Brain axis: is intestinal inflammation a silent driver of Park disease pathogenesis? NPJ Parkinsons Dis., 2017, 3, 3.

Bostanciklioğlu, M. The role of gut microbiota in pathogenesis of Alzheimer’s disease. J. Appl. Microbiol., 2019, 127(4), 954-967.
[http://dx.doi.org/10.1111/jam.14264] [PMID: 30920075]

Winner, B.; Kohl, Z.; Gage, F.H. Neurodegenerative disease and adult neurogenesis. Eur. J. Neurosci., 2011, 33(6), 1139-1151.
[http://dx.doi.org/10.1111/j.1460-9568.2011.07613.x] [PMID: 21395858]

Endres, K.; Schäfer, K.H. Influence of commensal microbiota on the enteric nervous system and its role in neurodegenerative diseases. J. Innate Immun., 2018, 10(3), 172-180.
[http://dx.doi.org/10.1159/000488629] [PMID: 29742516]

McCombe, P.A.; Henderson, R.D.; Lee, A.; Lee, J.D.; Woodruff, T.M.; Restuadi, R.; McRae, A.; Wray, N.R.; Ngo, S.; Steyn, F.J. Gut microbiota in ALS: possible role in pathogenesis? Expert Rev. Neurother., 2019, 19(9), 785-805.
[http://dx.doi.org/10.1080/14737175.2019.1623026] [PMID: 31122082]

Roy Sarkar, S.; Banerjee, S. Gut microbiota in neurodegenerative disorders. J. Neuroimmunol., 2019, 328, 98-104.
[http://dx.doi.org/10.1016/j.jneuroim.2019.01.004] [PMID: 30658292]

Sekirov, I.; Russell, S.L.; Antunes, L.C.M.; Finlay, B.B. Gut microbiota in health and disease. Physiol. Rev., 2016, 90(3), 859-904.

Wall, R.; Cryan, J.F.; Ross, R.P.; Fitzgerald, G.F.; Dinan, T.G.; Stanton, C. Bacterial neuroactive compounds produced by psychobiotics. Adv. Exp. Med. Biol., 2014, 817, 221-239.
[http://dx.doi.org/10.1007/978-1-4939-0897-4_10] [PMID: 24997036]

Ambrosini, Y.M.; Borcherding, D.; Kanthasamy, A.; Kim, H.J.; Willette, A.A.; Jergens, A.; Allenspach, K.; Mochel, J.P. The gut-brain axis in neurodegenerative diseases and relevance of the canine model: a review. Front. Aging Neurosci., 2019, 11, 130.
[http://dx.doi.org/10.3389/fnagi.2019.00130] [PMID: 31275138]

Erkkinen, M.G.; Kim, M.O.; Geschwind, M.D. Clinical neurology and epidemiology of the major neurodegenerative diseases. Cold Spring Harb. Perspect. Biol., 2018, 10(4), 10.
[http://dx.doi.org/10.1101/cshperspect.a033118] [PMID: 28716886]

Ursell, L.K.; Metcalf, J.L.; Parfrey, L.W.; Knight, R. Defining the human microbiome. Nutr. Rev., 2012, 70(Suppl. 1), S38-S44.
[http://dx.doi.org/10.1111/j.1753-4887.2012.00493.x] [PMID: 22861806]

Guarner, F.; Malagelada, J.R. Gut flora in health and disease. Lancet, 2003, 361(9356), 512-519.
[http://dx.doi.org/10.1016/S0140-6736(03)12489-0] [PMID: 12583961]

Quigley, E.M.M. Gut bacteria in health and disease. Gastroenterol. Hepatol. (N. Y.), 2013, 9(9), 560-569.
[PMID: 24729765]

Hirschberg, S.; Gisevius, B.; Duscha, A.; Haghikia, A. Implications of diet and the gut microbiome in neuroinflammatory and neurodegenerative diseases. Int. J. Mol. Sci., 2019, 20(12), 20.
[http://dx.doi.org/10.3390/ijms20123109] [PMID: 31242699]

Kimura, I.; Inoue, D.; Maeda, T.; Hara, T.; Ichimura, A.; Miyauchi, S.; Kobayashi, M.; Hirasawa, A.; Tsujimoto, G. Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41). Proc. Natl. Acad. Sci. USA, 2011, 108(19), 8030-8035.
[http://dx.doi.org/10.1073/pnas.1016088108] [PMID: 21518883]

Huttenhower, C.; Gevers, D.; Knight, R.; Abubucker, S.; Badger, J.H.; Chinwalla, A.T.; Creasy, H.H.; Earl, A.M.; Fitzgerald, M.G.; Fulton, R.S.; Giglio, M.G.; Hallsworth-Pepin, K.; Lobos, E.A.; Madupu, R.; Magrini, V.; Martin, J.C.; Mitreva, M.; Muzny, D.M.; Sodergren, E.J.; Versalovic, J.; Wollam, A.M.; Worley, K.C.; Wortman, J.R.; Young, S.K.; Zeng, Q.; Aagaard, K.M.; Abolude, O.O.; Allen-Vercoe, E.; Alm, E.J.; Alvarado, L.; Andersen, G.L.; Anderson, S.; Appelbaum, E.; Arachchi, H.M.; Armitage, G.; Arze, C.A.; Ayvaz, T.; Baker, C.C.; Begg, L.; Belachew, T.; Bhonagiri, V.; Bihan, M.; Blaser, M.J.; Bloom, T.; Bonazzi, V.; Paul Brooks, J.; Buck, G.A.; Buhay, C.J.; Busam, D.A.; Campbell, J.L.; Canon, S.R.; Cantarel, B.L.; Chain, P.S.G.; Chen, I.M.A.; Chen, L.; Chhibba, S.; Chu, K.; Ciulla, D.M.; Clemente, J.C.; Clifton, S.W.; Conlan, S.; Crabtree, J.; Cutting, M.A.; Davidovics, N.J.; Davis, C.C.; Desantis, T.Z.; Deal, C.; Delehaunty, K.D.; Dewhirst, F.E.; Deych, E.; Ding, Y.; Dooling, D.J.; Dugan, S.P.; Michael Dunne, W.; Scott Durkin, A.; Edgar, R.C.; Erlich, R.L.; Farmer, C.N.; Farrell, R.M.; Faust, K.; Feldgarden, M.; Felix, V.M.; Fisher, S.; Fodor, A.A.; Forney, L.J.; Foster, L.; Di Francesco, V.; Friedman, J.; Friedrich, D.C.; Fronick, C.C.; Fulton, L.L.; Gao, H.; Garcia, N.; Giannoukos, G.; Giblin, C.; Giovanni, M.Y.; Goldberg, J.M.; Goll, J.; Gonzalez, A.; Griggs, A.; Gujja, S.; Kinder Haake, S.; Haas, B.J.; Hamilton, H.A.; Harris, E.L.; Hepburn, T.A.; Herter, B.; Hoffmann, D.E.; Holder, M.E.; Howarth, C.; Huang, K.H.; Huse, S.M.; Izard, J.; Jansson, J.K.; Jiang, H.; Jordan, C.; Joshi, V.; Katancik, J.A.; Keitel, W.A.; Kelley, S.T.; Kells, C.; King, N.B.; Knights, D.; Kong, H.H.; Koren, O.; Koren, S.; Kota, K.C.; Kovar, C.L.; Kyrpides, N.C.; La Rosa, P.S.; Lee, S.L.; Lemon, K.P.; Lennon, N.; Lewis, C.M.; Lewis, L.; Ley, R.E.; Li, K.; Liolios, K.; Liu, B.; Liu, Y.; Lo, C.C.; Lozupone, C.A.; Dwayne Lunsford, R.; Madden, T.; Mahurkar, A.A.; Mannon, P.J.; Mardis, E.R.; Markowitz, V.M.; Mavromatis, K.; McCorrison, J.M.; McDonald, D.; McEwen, J.; McGuire, A.L.; McInnes, P.; Mehta, T.; Mihindukulasuriya, K.A.; Miller, J.R.; Minx, P.J.; Newsham, I.; Nusbaum, C.; Oglaughlin, M.; Orvis, J.; Pagani, I.; Palaniappan, K.; Patel, S.M.; Pearson, M.; Peterson, J.; Podar, M.; Pohl, C.; Pollard, K.S.; Pop, M.; Priest, M.E.; Proctor, L.M.; Qin, X.; Raes, J.; Ravel, J.; Reid, J.G.; Rho, M.; Rhodes, R.; Riehle, K.P.; Rivera, M.C.; Rodriguez-Mueller, B.; Rogers, Y.H.; Ross, M.C.; Russ, C.; Sanka, R.K.; Sankar, P.; Fah Sathirapongsasuti, J.; Schloss, J.A.; Schloss, P.D.; Schmidt, T.M.; Scholz, M.; Schriml, L.; Schubert, A.M.; Segata, N.; Segre, J.A.; Shannon, W.D.; Sharp, R.R.; Sharpton, T.J.; Shenoy, N.; Sheth, N.U.; Simone, G.A.; Singh, I.; Smillie, C.S.; Sobel, J.D.; Sommer, D.D.; Spicer, P.; Sutton, G.G.; Sykes, S.M.; Tabbaa, D.G.; Thiagarajan, M.; Tomlinson, C.M.; Torralba, M.; Treangen, T.J.; Truty, R.M.; Vishnivetskaya, T.A.; Walker, J.; Wang, L.; Wang, Z.; Ward, D.V.; Warren, W.; Watson, M.A.; Wellington, C.; Wetterstrand, K.A.; White, J.R.; Wilczek-Boney, K.; Wu, Y.; Wylie, K.M.; Wylie, T.; Yandava, C.; Ye, L.; Ye, Y.; Yooseph, S.; Youmans, B.P.; Zhang, L.; Zhou, Y.; Zhu, Y.; Zoloth, L.; Zucker, J.D.; Birren, B.W.; Gibbs, R.A.; Highlander, S.K.; Methé, B.A.; Nelson, K.E.; Petrosino, J.F.; Weinstock, G.M.; Wilson, R.K.; White, O. Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature, 2012, 486(7402), 207-214.
[http://dx.doi.org/10.1038/nature11234] [PMID: 22699609]

Boulos, C.; Yaghi, N.; El Hayeck, R.; Heraoui, G.N.; Fakhoury-Sayegh, N. Nutritional risk factors, microbiota and parkinson’s disease: what is the current evidence? Nutrients, 2019, 11(8), 1896.
[http://dx.doi.org/10.3390/nu11081896] [PMID: 31416163]

Gibson, G.R.; Roberfroid, M.B. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J. Nutr., 1995, 125(6), 1401-1412.
[http://dx.doi.org/10.1093/jn/125.6.1401] [PMID: 7782892]

Angelucci, F.; Cechova, K.; Amlerova, J.; Hort, J. Antibiotics, gut microbiota, and Alzheimer’s disease. J. Neuroinflammation, 2019, 16(1), 108.
[http://dx.doi.org/10.1186/s12974-019-1494-4] [PMID: 31118068]

De La Cochetière, M.F.; Durand, T.; Lepage, P.; Bourreille, A.; Galmiche, J.P.; Doré, J. Resilience of the dominant human fecal microbiota upon short-course antibiotic challenge. J. Clin. Microbiol., 2005, 43(11), 5588-5592.
[http://dx.doi.org/10.1128/JCM.43.11.5588-5592.2005] [PMID: 16272491]

Bartosch, S.; Fite, A.; Macfarlane, G.T.; McMurdo, M.E.T. Characterization of bacterial communities in feces from healthy elderly volunteers and hospitalized elderly patients by using real-time PCR and effects of antibiotic treatment on the fecal microbiota. Appl. Environ. Microbiol., 2004, 70(6), 3575-3581.
[http://dx.doi.org/10.1128/AEM.70.6.3575-3581.2004] [PMID: 15184159]

Jernberg, C.; Löfmark, S.; Edlund, C.; Jansson, J.K. Long-term ecological impacts of antibiotic administration on the human intestinal microbiota. ISME J., 2007, 1(1), 56-66.
[http://dx.doi.org/10.1038/ismej.2007.3] [PMID: 18043614]

Fouhy, F.; Guinane, C.M.; Hussey, S.; Wall, R.; Ryan, C.A.; Dempsey, E.M.; Murphy, B.; Ross, R.P.; Fitzgerald, G.F.; Stanton, C.; Cotter, P.D. High-throughput sequencing reveals the incomplete, short-term recovery of infant gut microbiota following parenteral antibiotic treatment with ampicillin and gentamicin. Antimicrob. Agents Chemother., 2012, 56(11), 5811-5820.
[http://dx.doi.org/10.1128/AAC.00789-12] [PMID: 22948872]

Boehme, M.; van de Wouw, M.; Bastiaanssen, T.F.S.; Olavarría-Ramírez, L.; Lyons, K.; Fouhy, F.; Golubeva, A.V.; Moloney, G.M.; Minuto, C.; Sandhu, K.V.; Scott, K.A.; Clarke, G.; Stanton, C.; Dinan, T.G.; Schellekens, H.; Cryan, J.F. Mid-life microbiota crises: middle age is associated with pervasive neuroimmune alterations that are reversed by targeting the gut microbiome. Mol. Psychiatry, 2019.
[http://dx.doi.org/10.1038/s41380-019-0425-1] [PMID: 31092898]

Thomas, C.M.; Hong, T.; van Pijkeren, J.P.; Hemarajata, P.; Trinh, D.V.; Hu, W.; Britton, R.A.; Kalkum, M.; Versalovic, J. Histamine derived from probiotic Lactobacillus reuteri suppresses TNF via modulation of PKA and ERK signaling. PLoS One, 2012, 7(2), e31951
[http://dx.doi.org/10.1371/journal.pone.0031951] [PMID: 22384111]

Rhee, S.H.; Pothoulakis, C.; Mayer, E.A. Principles and clinical implications of the brain-gut-enteric microbiota axis. Nat. Rev. Gastroenterol. Hepatol., 2009, 6(5), 306-314.
[http://dx.doi.org/10.1038/nrgastro.2009.35] [PMID: 19404271]

Collins, S.M.; Bercik, P. The relationship between intestinal microbiota and the central nervous system in normal gastrointestinal function and disease. Gastroenterology, 2009, 136(6), 2003-2014.
[http://dx.doi.org/10.1053/j.gastro.2009.01.075] [PMID: 19457424]

Dinan, T.G.; Cryan, J.F. Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration. J. Physiol., 2017, 595(2), 489-503.
[http://dx.doi.org/10.1113/JP273106] [PMID: 27641441]

Cryan, J.F.; O’Mahony, S.M. The microbiome-gut-brain axis: from bowel to behavior. Neurogastroenterol. Motil., 2011, 23(3), 187-192.
[http://dx.doi.org/10.1111/j.1365-2982.2010.01664.x] [PMID: 21303428]

Forsythe, P.; Bienenstock, J.; Kunze, W.A. Vagal pathways for microbiome-brain-gut axis communication. Adv. Exp. Med. Biol., 2014, 817, 115-133.
[http://dx.doi.org/10.1007/978-1-4939-0897-4_5] [PMID: 24997031]

Fülling, C.; Dinan, T.G.; Cryan, J.F. Gut microbe to brain signaling: what happens in vagus…. Neuron, 2019, 101(6), 998-1002.
[http://dx.doi.org/10.1016/j.neuron.2019.02.008] [PMID: 30897366]

Kaelberer, M.M.; Buchanan, K.L.; Klein, M.E.; Barth, B.B.; Montoya, M.M.; Shen, X.; Bohórquez, D.V. A gut-brain neural circuit for nutrient sensory transduction. Science, 2018, 361(6408),pii: eaat5236

Forsythe, P.; Sudo, N.; Dinan, T.; Taylor, V.H.; Bienenstock, J. Mood and gut feelings. Brain Behav. Immun., 2010, 24(1), 9-16.
[http://dx.doi.org/10.1016/j.bbi.2009.05.058] [PMID: 19481599]

Hsiao, E.Y.; McBride, S.W.; Hsien, S.; Sharon, G.; Hyde, E.R.; McCue, T.; Codelli, J.A.; Chow, J.; Reisman, S.E.; Petrosino, J.F.; Patterson, P.H.; Mazmanian, S.K. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell, 2013, 155(7), 1451-1463.
[http://dx.doi.org/10.1016/j.cell.2013.11.024] [PMID: 24315484]

Kihara, N.; Fujimura, M.; Yamamoto, I.; Itoh, E.; Inui, A.; Fujimiya, M. Effects of central and peripheral urocortin on fed and fasted gastroduodenal motor activity in conscious rats. Am. J. Physiol. Gastrointest. Liver Physiol., 2001, 280(3), G406-G419.
[http://dx.doi.org/10.1152/ajpgi.2001.280.3.G406] [PMID: 11171623]

Zheng, G.; Wu, S-P.; Hu, Y.; Smith, D.E.; Wiley, J.W.; Hong, S. Corticosterone mediates stress-related increased intestinal permeability in a region-specific manner. Neurogastroenterol. Motil., 2013, 25(2), e127-e139.
[http://dx.doi.org/10.1111/nmo.12066] [PMID: 23336591]

Dinan, T.G.; Quigley, E.M.M.; Ahmed, S.M.M.; Scully, P.; O’Brien, S.; O’Mahony, L.; O’Mahony, S.; Shanahan, F.; Keeling, P.W.N. Hypothalamic-pituitary-gut axis dysregulation in irritable bowel syndrome: plasma cytokines as a potential biomarker? Gastroenterology, 2006, 130(2), 304-311.
[http://dx.doi.org/10.1053/j.gastro.2005.11.033] [PMID: 16472586]

Yano, J.M.; Yu, K.; Donaldson, G.P.; Shastri, G.G.; Ann, P.; Ma, L.; Nagler, C.R.; Ismagilov, R.F.; Mazmanian, S.K.; Elaine, Y. HHS Public Access., 2016, 161, 264-276.

Shishov, V.A.; Kirovskaia, T.A.; Kudrin, V.S.; Oleskin, A.V. [Amine neuromediators, their precursors, and oxidation products in the culture of Escherichia coli K-12]. Prikl. Biokhim. Mikrobiol., 2009, 45(5), 550-554.
[PMID: 19845286]

Iyer, L.M.; Aravind, L.; Coon, S.L.; Klein, D.C.; Koonin, E.V. Evolution of cell-cell signaling in animals: did late horizontal gene transfer from bacteria have a role? Trends Genet., 2004, 20(7), 292-299.
[http://dx.doi.org/10.1016/j.tig.2004.05.007] [PMID: 15219393]

Barrett, E.; Ross, R.P.; O’Toole, P.W.; Fitzgerald, G.F.; Stanton, C. γ-Aminobutyric acid production by culturable bacteria from the human intestine. J. Appl. Microbiol., 2012, 113(2), 411-417.
[http://dx.doi.org/10.1111/j.1365-2672.2012.05344.x] [PMID: 22612585]

Kawashima, K.; Misawa, H.; Moriwaki, Y.; Fujii, Y.X.; Fujii, T.; Horiuchi, Y.; Yamada, T.; Imanaka, T.; Kamekura, M. Ubiquitous expression of acetylcholine and its biological functions in life forms without nervous systems. Life Sci., 2007, 80(24-25), 2206-2209.
[http://dx.doi.org/10.1016/j.lfs.2007.01.059] [PMID: 17363003]

Gareau, M.G.; Wine, E.; Rodrigues, D.M.; Cho, J.H.; Whary, M.T.; Philpott, D.J.; Macqueen, G.; Sherman, P.M. Bacterial infection causes stress-induced memory dysfunction in mice. Gut, 2011, 60(3), 307-317.
[http://dx.doi.org/10.1136/gut.2009.202515] [PMID: 20966022]

Bravo, J.A.; Forsythe, P.; Chew, M.V.; Escaravage, E.; Savignac, H.M.; Dinan, T.G.; Bienenstock, J.; Cryan, J.F. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc. Natl. Acad. Sci. USA, 2011, 108(38), 16050-16055.
[http://dx.doi.org/10.1073/pnas.1102999108] [PMID: 21876150]

Novotný, M.; Klimova, B.; Valis, M. Microbiome and cognitive impairment: can any diets influence learning processes in a positive way? Front. Aging Neurosci., 2019, 11, 170.
[http://dx.doi.org/10.3389/fnagi.2019.00170] [PMID: 31316375]

Dinan, T.G.; Stilling, R.M.; Stanton, C.; Cryan, J.F. Collective unconscious: how gut microbes shape human behavior. J. Psychiatr. Res., 2015, 63, 1-9.
[http://dx.doi.org/10.1016/j.jpsychires.2015.02.021] [PMID: 25772005]

Klingelhoefer, L.; Reichmann, H. Pathogenesis of Parkinson disease--the gut-brain axis and environmental factors. Nat. Rev. Neurol., 2015, 11(11), 625-636.
[http://dx.doi.org/10.1038/nrneurol.2015.197] [PMID: 26503923]

Scheperjans, F.; Aho, V.; Pereira, P.A.B.; Koskinen, K.; Paulin, L.; Pekkonen, E.; Haapaniemi, E.; Kaakkola, S.; Eerola-Rautio, J.; Pohja, M.; Kinnunen, E.; Murros, K.; Auvinen, P. Gut microbiota are related to Parkinson’s disease and clinical phenotype. Mov. Disord., 2015, 30(3), 350-358.
[http://dx.doi.org/10.1002/mds.26069] [PMID: 25476529]

Klingelhoefer, L.; Reichmann, H. Pathogenesis of Parkinson disease--the gut-brain axis and environmental factors. Nat. Publ. Gr, 2015, 11(11), 625-636.

Sampson, T.R.; Debelius, J.W.; Thron, T.; Janssen, S.; Shastri, G.G.; Ilhan, Z.E.; Challis, C.; Schretter, C.E.; Rocha, S.; Gradinaru, V.; Chesselet, M.F.; Keshavarzian, A.; Shannon, K.M.; Krajmalnik-Brown, R.; Wittung-Stafshede, P.; Knight, R.; Mazmanian, S.K. Gut microbiota regulate motor deficits and neuroinflammation in a model of parkinson’s disease. Cell, 2016, 167(6), 1469-1480.e12.
[http://dx.doi.org/10.1016/j.cell.2016.11.018] [PMID: 27912057]

Caputi, V.; Giron, M.C. Microbiome-gut-brain axis and toll-like receptors in parkinson’s disease. Int. J. Mol. Sci., 2018, 19(6), 19.
[http://dx.doi.org/10.3390/ijms19061689] [PMID: 29882798]

Keshavarzian, A.; Green, S.J.; Engen, P.A.; Voigt, R.M.; Naqib, A.; Forsyth, C.B.; Mutlu, E.; Shannon, K.M. Colonic bacterial composition in Parkinson’s disease. Mov. Disord., 2015, 30(10), 1351-1360.
[http://dx.doi.org/10.1002/mds.26307] [PMID: 26179554]

Bedarf, J.R.; Hildebrand, F.; Coelho, L.P.; Sunagawa, S.; Bahram, M.; Goeser, F.; Bork, P.; Wüllner, U. Functional implications of microbial and viral gut metagenome changes in early stage l-dopanaïve parkinson’s disease patients. Genome Med., 2017, 9(1), 39.

Campos-Acuña, J.; Elgueta, D.; Pacheco, R. T-cell-driven inflammation as a mediator of the gut-brain axis involved in parkinson’s disease. Front. Immunol., 2019, 10, 239.
[http://dx.doi.org/10.3389/fimmu.2019.00239] [PMID: 30828335]

Çamcı, G.; Oğuz, S. Association between parkinson’s disease and helicobacter pylori. J. Clin. Neurol., 2016, 12(2), 147-150.
[http://dx.doi.org/10.3988/jcn.2016.12.2.147] [PMID: 26932258]

Dardiotis, E.; Tsouris, Z.; Mentis, A.A.; Siokas, V.; Michalopoulou, A.; Sokratous, M.; Dastamani, M.; Bogdanos, D.P.; Deretzi, G.; Kountouras, J. H. pylori and Parkinson’s disease: Meta-analyses including clinical severity. Clin. Neurol. Neurosurg., 2018, 175, 16-24.
[http://dx.doi.org/10.1016/j.clineuro.2018.09.039] [PMID: 30308319]

Huang, H.K.; Wang, J.H.; Lei, W.Y.; Chen, C.L.; Chang, C.Y.; Liou, L.S. Helicobacter pylori infection is associated with an increased risk of Parkinson’s disease: A population-based retrospective cohort study. Parkinsonism Relat. Disord., 2018, 47, 26-31.
[http://dx.doi.org/10.1016/j.parkreldis.2017.11.331] [PMID: 29174171]

Holmqvist, S.; Chutna, O.; Bousset, L.; Aldrin-Kirk, P.; Li, W.; Björklund, T.; Wang, Z.Y.; Roybon, L.; Melki, R.; Li, J.Y. Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats. Acta Neuropathol., 2014, 128(6), 805-820.
[http://dx.doi.org/10.1007/s00401-014-1343-6] [PMID: 25296989]

Braak, H.; Del Tredici, K.; Rüb, U.; de Vos, R.A.I.; Jansen Steur, E.N.H.; Braak, E. Staging of brain pathology related to sporadic Parkinson’s disease. Neurobiol. Aging, 2003, 24(2), 197-211.
[http://dx.doi.org/10.1016/S0197-4580(02)00065-9] [PMID: 12498954]

Chen, S.G.; Stribinskis, V.; Rane, M.J.; Demuth, D.R.; Gozal, E.; Roberts, A.M.; Jagadapillai, R.; Liu, R.; Choe, K.; Shivakumar, B.; Son, F.; Jin, S.; Kerber, R.; Adame, A.; Masliah, E.; Friedland, R.P. Exposure to the functional bacterial amyloid protein curli enhances alpha-synuclein aggregation in aged fischer 344 rats and caenorhabditis elegans. Sci. Rep., 2016, 6, 34477.
[http://dx.doi.org/10.1038/srep34477] [PMID: 27708338]

Matheoud, D.; Cannon, T.; Voisin, A.; Penttinen, A-M.; Ramet, L.; Fahmy, A.M.; Ducrot, C.; Laplante, A.; Bourque, M-J.; Zhu, L.; Cayrol, R.; Le Campion, A.; McBride, H.M.; Gruenheid, S.; Trudeau, L-E.; Desjardins, M. Intestinal infection triggers Parkinson’s disease-like symptoms in Pink1^-/- mice. Nature, 2019, 571(7766), 565-569.
[http://dx.doi.org/10.1038/s41586-019-1405-y] [PMID: 31316206]

Braak, H.; Braak, E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol., 1991, 82(4), 239-259.
[http://dx.doi.org/10.1007/BF00308809] [PMID: 1759558]

Oakley, H.; Cole, S.L.; Logan, S.; Maus, E.; Shao, P.; Craft, J.; Guillozet-Bongaarts, A.; Ohno, M.; Disterhoft, J.; Van Eldik, L.; Berry, R.; Vassar, R. Intraneuronal β-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer’s disease mutations: potential factors in amyloid plaque formation. J. Neurosci., 2006, 26(40), 10129-10140.
[http://dx.doi.org/10.1523/JNEUROSCI.1202-06.2006] [PMID: 17021169]

Brandscheid, C.; Schuck, F.; Reinhardt, S.; Schäfer, K.H.; Pietrzik, C.U.; Grimm, M.; Hartmann, T.; Schwiertz, A.; Endres, K. Altered gut microbiome composition and tryptic activity of the 5xfad alzheimer’s mouse model. J. Alzheimers Dis., 2017, 56(2), 775-788.
[http://dx.doi.org/10.3233/JAD-160926] [PMID: 28035935]

Jankowsky, J.L.; Fadale, D.J.; Anderson, J.; Xu, G.M.; Gonzales, V.; Jenkins, N.A.; Copeland, N.G.; Lee, M.K.; Younkin, L.H.; Wagner, S.L.; Younkin, S.G.; Borchelt, D.R. Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase. Hum. Mol. Genet., 2004, 13(2), 159-170.
[http://dx.doi.org/10.1093/hmg/ddh019] [PMID: 14645205]

Harach, T.; Marungruang, N.; Duthilleul, N.; Cheatham, V.; Mc Coy, K.D.; Frisoni, G.; Neher, J.J.; Fåk, F.; Jucker, M.; Lasser, T.; Bolmont, T. Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota. Sci. Rep., 2017, 7, 41802.
[http://dx.doi.org/10.1038/srep41802] [PMID: 28176819]

Cattaneo, A.; Cattane, N.; Galluzzi, S.; Provasi, S.; Lopizzo, N.; Festari, C.; Ferrari, C.; Guerra, U.P.; Paghera, B.; Muscio, C.; Bianchetti, A.; Volta, G.D.; Turla, M.; Cotelli, M.S.; Gennuso, M.; Prelle, A.; Zanetti, O.; Lussignoli, G.; Mirabile, D.; Bellandi, D.; Gentile, S.; Belotti, G.; Villani, D.; Harach, T.; Bolmont, T.; Padovani, A.; Boccardi, M.; Frisoni, G.B. INDIA-FBP Group. Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly. Neurobiol. Aging, 2017, 49, 60-68.
[http://dx.doi.org/10.1016/j.neurobiolaging.2016.08.019] [PMID: 27776263]

Vogt, N.M.; Kerby, R.L.; Dill-McFarland, K.A.; Harding, S.J.; Merluzzi, A.P.; Johnson, S.C.; Carlsson, C.M.; Asthana, S.; Zetterberg, H.; Blennow, K.; Bendlin, B.B.; Rey, F.E. Gut microbiome alterations in Alzheimer’s disease. Sci. Rep., 2017, 7(1), 13537.
[http://dx.doi.org/10.1038/s41598-017-13601-y] [PMID: 29051531]

Roubaud-Baudron, C.; Krolak-Salmon, P.; Quadrio, I.; Mégraud, F.; Salles, N. Impact of chronic Helicobacter pylori infection on Alzheimer’s disease: preliminary results. Neurobiol. Aging, 2012, 33(5), 1009.e11-1009.e19.
[http://dx.doi.org/10.1016/j.neurobiolaging.2011.10.021] [PMID: 22133280]

Wu, S.C.; Cao, Z.S.; Chang, K.M.; Juang, J.L. Intestinal microbial dysbiosis aggravates the progression of Alzheimer’s disease in Drosophila. Nat. Commun., 2017, 8(1), 24.
[http://dx.doi.org/10.1038/s41467-017-00040-6] [PMID: 28634323]

Spielman, L.J.; Gibson, D.L.; Klegeris, A. Unhealthy gut, unhealthy brain: The role of the intestinal microbiota in neurodegenerative diseases. Neurochem. Int., 2018, 120, 149-163.
[http://dx.doi.org/10.1016/j.neuint.2018.08.005] [PMID: 30114473]

Sochocka, M.; Donskow-Łysoniewska, K.; Diniz, B.S.; Kurpas, D.; Brzozowska, E.; Leszek, J. The gut microbiome alterations and inflammation-driven pathogenesis of alzheimer’s disease-a critical review. Mol. Neurobiol., 2019, 56(3), 1841-1851.
[http://dx.doi.org/10.1007/s12035-018-1188-4] [PMID: 29936690]

Yano, J.M.; Yu, K.; Donaldson, G.P.; Shastri, G.G.; Ann, P.; Ma, L.; Nagler, C.R.; Ismagilov, R.F.; Mazmanian, S.K.; Hsiao, E.Y. Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis. Cell, 2015, 161(2), 264-276.
[http://dx.doi.org/10.1016/j.cell.2015.02.047] [PMID: 25860609]

Watts, C.R.; Vanryckeghem, M. Laryngeal dysfunction in Amyotrophic Lateral Sclerosis: a review and case report. BMC Ear Nose Throat Disord., 2001, 1(1), 1-5.
[http://dx.doi.org/10.1186/1472-6815-1-1] [PMID: 11722802]

Swarup, V.; Phaneuf, D.; Bareil, C.; Robertson, J.; Rouleau, G.A.; Kriz, J.; Julien, J.P. Pathological hallmarks of amyotrophic lateral sclerosis/frontotemporal lobar degeneration in transgenic mice produced with TDP-43 genomic fragments. Brain, 2011, 134(Pt 9), 2610-2626.
[http://dx.doi.org/10.1093/brain/awr159] [PMID: 21752789]

Fang, X.; Wang, X.; Yang, S.; Meng, F.; Wang, X.; Wei, H.; Chen, T. Evaluation of the microbial diversity in amyotrophic lateral sclerosis using high-throughput sequencing. Front. Microbiol., 2016, 7, 1479.
[http://dx.doi.org/10.3389/fmicb.2016.01479] [PMID: 27703453]

Toepfer, M.; Folwaczny, C.; Klauser, A.; Riepl, R.L.; Müller-Felber, W.; Pongratz, D. Gastrointestinal dysfunction in amyotrophic lateral sclerosis. Amyotroph. Lateral Scler. Other Motor Neuron Disord., 1999, 1(1), 15-19.
[http://dx.doi.org/10.1080/146608299300079484] [PMID: 12365061]

Rowin, J.; Xia, Y.; Jung, B.; Sun, J. Gut inflammation and dysbiosis in human motor neuron disease. Physiol. Rep., 2017, 5(18), 5.
[http://dx.doi.org/10.14814/phy2.13443] [PMID: 28947596]

Brenner, D.; Yilmaz, R.; Müller, K.; Grehl, T.; Petri, S.; Meyer, T.; Grosskreutz, J.; Weydt, P.; Ruf, W.; Neuwirth, C.; Weber, M.; Pinto, S.; Claeys, K.G.; Schrank, B.; Jordan, B.; Knehr, A.; Günther, K.; Hübers, A.; Zeller, D.; Kubisch, C.; Jablonka, S.; Sendtner, M.; Klopstock, T.; de Carvalho, M.; Sperfeld, A.; Borck, G.; Volk, A.E.; Dorst, J.; Weis, J.; Otto, M.; Schuster, J.; Del Tredici, K.; Braak, H.; Danzer, K.M.; Freischmidt, A.; Meitinger, T.; Strom, T.M.; Ludolph, A.C.; Andersen, P.M.; Weishaupt, J.H.; Weyen, U.; Hermann, A.; Hagenacker, T.; Koch, J.C.; Lingor, P.; Göricke, B.; Zierz, S.; Baum, P.; Wolf, J.; Winkler, A.; Young, P.; Bogdahn, U.; Prudlo, J.; Kassubek, J. German ALS network MND-NET. Hot-spot KIF5A mutations cause familial ALS. Brain, 2018, 141(3), 688-697.
[http://dx.doi.org/10.1093/brain/awx370] [PMID: 29342275]

Mazzini, L.; Ferrari, D.; Andjus, P.R.; Buzanska, L.; Cantello, R.; De Marchi, F.; Gelati, M.; Giniatullin, R.; Glover, J.C.; Grilli, M.; Kozlova, E.N.; Maioli, M.; Mitrečić, D.; Pivoriunas, A.; Sanchez-Pernaute, R.; Sarnowska, A.; Vescovi, A.L. BIONECA COST ACTION WG Neurology. Advances in stem cell therapy for amyotrophic lateral sclerosis. Expert Opin. Biol. Ther., 2018, 18(8), 865-881.
[http://dx.doi.org/10.1080/14712598.2018.1503248] [PMID: 30025485]

Love, S. Demyelinating diseases. J. Clin. Pathol., 2006, 59(11), 1151-1159.
[http://dx.doi.org/10.1136/jcp.2005.031195] [PMID: 17071802]

Dos Passos, G.R.; Sato, D.K.; Becker, J.; Fujihara, K. Th17 Cells pathways in multiple sclerosis and neuromyelitis optica spectrum disorders: pathophysiological and therapeutic implications. Mediators of Inflammation, 2016, 2016, 5314541 [ePub Ahead of Print].

Cekanaviciute, E.; Yoo, B.B.; Runia, T.F.; Debelius, J.W.; Singh, S.; Nelson, C.A.; Kanner, R.; Bencosme, Y.; Lee, Y.K.; Hauser, S.L.; Crabtree-Hartman, E.; Sand, I.K.; Gacias, M.; Zhu, Y.; Casaccia, P.; Cree, B.A.C.; Knight, R.; Mazmanian, S.K.; Baranzini, S.E. Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models. Proc. Natl. Acad. Sci. USA, 2017, 114(40), 10713-10718.
[http://dx.doi.org/10.1073/pnas.1711235114] [PMID: 28893978]

Tremlett, H.; Waubant, E. Gut microbiome and pediatric multiple sclerosis. Mult. Scler., 2018, 24(1), 64-68.
[http://dx.doi.org/10.1177/1352458517737369] [PMID: 29307301]

Tremlett, H.; Fadrosh, D.W.; Faruqi, A.A.; Zhu, F.; Hart, J.; Roalstad, S.; Graves, J.; Lynch, S.; Waubant, E. US Network of Pediatric MS Centers. Gut microbiota in early pediatric multiple sclerosis: a case-control study. Eur. J. Neurol., 2016, 23(8), 1308-1321.
[http://dx.doi.org/10.1111/ene.13026] [PMID: 27176462]

Ma, Q.; Xing, C.; Long, W.; Wang, H.Y.; Liu, Q.; Wang, R.F. Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis. J. Neuroinflammation, 2019, 16(1), 53.
[http://dx.doi.org/10.1186/s12974-019-1434-3] [PMID: 30823925]

Kong, G.; Cao, K.A.L.; Judd, L.M.; Li, S.S.; Renoir, T.; Hannan, A.J. Microbiome profiling reveals gut dysbiosis in a transgenic mouse model of Huntington’s disease. Neurobiol. Dis., 2020, 135, 104268
[PMID: 30194046]

Radulescu, C.I.; Garcia-Miralles, M.; Sidik, H.; Bardile, C.F.; Yusof, N.A.B.M.; Lee, H.U.; Ho, E.X.P.; Chu, C.W.; Layton, E.; Low, D.; De Sessions, P.F.; Pettersson, S.; Ginhoux, F.; Pouladi, M.A. Manipulation of microbiota reveals altered callosal myelination and white matter plasticity in a model of Huntington disease. Neurobiol. Dis., 2019, 127, 65-75.
[http://dx.doi.org/10.1016/j.nbd.2019.02.011] [PMID: 30802499]

Foster, J.A.; McVey Neufeld, K.A. Gut-brain axis: how the microbiome influences anxiety and depression. Trends Neurosci., 2013, 36(5), 305-312.
[http://dx.doi.org/10.1016/j.tins.2013.01.005] [PMID: 23384445]

Li, S.; Hua, D.; Wang, Q.; Yang, L.; Wang, X.; Luo, A.; Yang, C. The role of bacteria and its derived metabolites in chronic pain and depression: recent findings and research progress. Int. J. Neuropsychopharmacol., 2019, 23(1), 26-41.
[PMID: 31760425]

Russo, R.; Cristiano, C.; Avagliano, C.; De Caro, C.; La Rana, G.; Raso, G.M.; Canani, R.B.; Meli, R.; Calignano, A. Gut-brain axis: role of lipids in the regulation of inflammation, pain and CNS diseases. Curr. Med. Chem., 2018, 25(32), 3930-3952.
[http://dx.doi.org/10.2174/0929867324666170216113756] [PMID: 28215162]

Mayer, E.A.; Tillisch, K. The brain-gut axis in abdominal pain syndromes. Annu. Rev. Med., 2011, 62, 381-396.
[http://dx.doi.org/10.1146/annurev-med-012309-103958] [PMID: 21090962]

Carlessi, A.S.; Borba, L.A.; Zugno, A.I.; Quevedo, J.; Réus, G.Z. Gut microbiota-brain axis in depression: The role of neuroinflammation. Eur. J. Neurosci., 2019. [Online ahead of Print].

Vuong, H.E.; Hsiao, E.Y. Emerging roles for the gut microbiome in autism spectrum disorder. Biol. Psychiatry, 2017, 81(5), 411-423.
[http://dx.doi.org/10.1016/j.biopsych.2016.08.024] [PMID: 27773355]

Tomova, A.; Soltys, K.; Repiska, G.; Palkova, L.; Filcikova, D.; Minarik, G.; Turna, J.; Prochotska, K.; Babinska, K.; Ostatnikova, D. Specificity of gut microbiota in children with autism spectrum disorder in Slovakia and its correlation with astrocytes activity marker and specific behavioural patterns. Physiol. Behav., 2020, 214, 112745
[http://dx.doi.org/10.1016/j.physbeh.2019.112745] [PMID: 31765662]

Gabriel, T.; Paul, S.; Berger, A.; Massoubre, C. Anorexia nervosa and autism spectrum disorders: future hopes linked to mucosal immunity. Neuroimmunomodulation, 2019, 26(6), 265-275.
[http://dx.doi.org/10.1159/000502997] [PMID: 31715599]

Flowers, S.A.; Ward, K.M.; Clark, C.T. The gut microbiome in bipolar disorder and pharmacotherapy management. Neuropsychobiology, 2019, 79(1), 43-49.
[PMID: 31722343]

Bull-Larsen, S.; Mohajeri, M.H. The potential influence of the bacterial microbiome on the development and progression of ADHD. Nutrients, 2019, 11(11), 2805.
[http://dx.doi.org/10.3390/nu11112805]

Borghi, E.; Vignoli, A. Rett syndrome and other neurodevelopmental disorders share common changes in gut microbial community: a descriptive review. Int. J. Mol. Sci., 2019, 20(17), 4160.
[http://dx.doi.org/10.3390/ijms20174160] [PMID: 31454888]

Zhang, Z.; Tang, H.; Chen, P.; Xie, H.; Tao, Y. Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome. Signal Transduct. Target. Ther., 2019, 4, 41.

Horvath, K.; Perman, J.A. Autism and gastrointestinal symptoms. Curr. Gastroenterol. Rep., 2002, 4(3), 251-258.
[http://dx.doi.org/10.1007/s11894-002-0071-6] [PMID: 12010627]

Adams, J.B.; Johansen, L.J.; Powell, L.D.; Quig, D.; Rubin, R.A. Gastrointestinal flora and gastrointestinal status in children with autism--comparisons to typical children and correlation with autism severity. BMC Gastroenterol., 2011, 11, 22.
[http://dx.doi.org/10.1186/1471-230X-11-22] [PMID: 21410934]

Bharwani, A.; Mian, M.F.; Foster, J.A.; Surette, M.G.; Bienenstock, J.; Forsythe, P. Structural & functional consequences of chronic psychosocial stress on the microbiome & host. Psychoneuroendocrinology, 2016, 63, 217-227.
[http://dx.doi.org/10.1016/j.psyneuen.2015.10.001] [PMID: 26479188]

Rea, K.; Dinan, T.G.; Cryan, J.F. The microbiome: A key regulator of stress and neuroinflammation. Neurobiol. Stress, 2016, 4, 23-33.
[http://dx.doi.org/10.1016/j.ynstr.2016.03.001] [PMID: 27981187]

Rea, K.; Dinan, T.G.; Cryan, J.F. Gut microbiota: a perspective for psychiatrists. Neuropsychobiol, 2020, 79, 50-62.
[PMID: 31726457]

Bailey, M.T. Influence of stressor-induced nervous system activation on the intestinal microbiota and the importance for immunomodulation. Adv. Exp. Med. Biol., 2014, 817, 255-276.
[http://dx.doi.org/10.1007/978-1-4939-0897-4_12] [PMID: 24997038]

Sudo, N.; Chida, Y.; Aiba, Y.; Sonoda, J.; Oyama, N.; Yu, X.N.; Kubo, C.; Koga, Y. Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice. J. Physiol., 2004, 558(Pt 1), 263-275.
[http://dx.doi.org/10.1113/jphysiol.2004.063388] [PMID: 15133062]

Yang, C.; Gao, J.; Zhang, J.; Luo, A.L. Enterochromaffin cells in the gut: a distant regulator of brain function? Gut, 2018, 67(8), 1557-1558.
[http://dx.doi.org/10.1136/gutjnl-2017-315406] [PMID: 29080857]

Yang, C.; Fujita, Y.; Ren, Q.; Ma, M.; Dong, C.; Hashimoto, K. Bifidobacterium in the gut microbiota confer resilience to chronic social defeat stress in mice. Sci. Rep., 2017, 7, 45942.
[http://dx.doi.org/10.1038/srep45942] [PMID: 28368029]

Bercik, P.; Park, A.J.; Sinclair, D.; Khoshdel, A.; Lu, J.; Huang, X.; Deng, Y.; Blennerhassett, P.A.; Fahnestock, M.; Moine, D.; Berger, B.; Huizinga, J.D.; Kunze, W.; McLean, P.G.; Bergonzelli, G.E.; Collins, S.M.; Verdu, E.F. The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication. Neurogastroenterol. Motil., 2011, 23(12), 1132-1139.
[http://dx.doi.org/10.1111/j.1365-2982.2011.01796.x] [PMID: 21988661]

Coury, D.L.; Ashwood, P.; Fasano, A.; Fuchs, G.; Geraghty, M.; Kaul, A.; Mawe, G.; Patterson, P.; Jones, N.E. Gastrointestinal conditions in children with autism spectrum disorder: developing a research agenda. Pediatrics, 2012, 130(Suppl. 2), S160-S168.
[http://dx.doi.org/10.1542/peds.2012-0900N] [PMID: 23118247]

Hsiao, E.Y.; Mcbride, S.W.; Hsien, S.; Sharon, G.; Hyde, E.R.; Mccue, T.; Codelli, J.A.; Chow, J.; Reisman, S.E.; Petrosino, J.F.; Patterson, P.H.; Mazmanian, S.K. Autism spectrum disorder fact sheet. Abnormalities Associated with Autism., 2014, 155, 1451-1463.

Rose, D.R.; Yang, H.; Serena, G.; Sturgeon, C.; Ma, B.; Careaga, M.; Hughes, H.K.; Angkustsiri, K.; Rose, M.; Hertz-Picciotto, I.; Van de Water, J.; Hansen, R.L.; Ravel, J.; Fasano, A.; Ashwood, P. Differential immune responses and microbiota profiles in children with autism spectrum disorders and co-morbid gastrointestinal symptoms. Brain Behav. Immun., 2018, 70, 354-368.
[http://dx.doi.org/10.1016/j.bbi.2018.03.025] [PMID: 29571898]

Li, N.; Yang, J.; Zhang, J.; Liang, C.; Wang, Y.; Chen, B.; Zhao, C.; Wang, J.; Zhang, G.; Zhao, D.; Liu, Y.; Zhang, L.; Yang, J.; Li, G.; Gai, Z.; Zhang, L.; Zhao, G. Correlation of Gut Microbiome Between ASD Children and Mothers and Potential Biomarkers for Risk Assessment. GBP, 2019, 17(1), 26-38.
[http://dx.doi.org/10.1016/j.gpb.2019.01.002] [PMID: 31026579]

Sgritta, M.; Dooling, S.W.; Buffington, S.A.; Momin, E.N.; Francis, M.B.; Britton, R.A.; Costa-Mattioli, M.; Dooling, S.W.; Buffington, S.A.; Momin, E.N.; Francis, M.B.; Britton, R.A. Mechanisms underlying microbial-mediated changes in social behavior in mouse models of autism spectrum disorder. Neuron, 2019, 101(2), 246-259.e6.
[http://dx.doi.org/10.1016/j.neuron.2018.11.018] [PMID: 30522820]

Stobernack, T.; De Vries, S.P.W.; Pereira, R.R. Biomarker research in adhd: the impact of nutrition (brain) - study protocol of an openlabel trial to investigate the mechanisms underlying the effects of a few-foods diet on adhd symptoms in children. BMJ Open, 2019, 9(11), e029422

Borghi, E.; Borgo, F.; Severgnini, M.; Savini, M.N.; Casiraghi, M.C.; Vignoli, A. Rett Syndrome: A Focus on Gut Microbiota. Int. J. Mol. Sci., 2017, 18(2), 344.
[http://dx.doi.org/10.3390/ijms18020344] [PMID: 28178201]

Blaser, M.J. Fecal Microbiota transplantation for dysbiosis - predictable risks. N. Engl. J. Med., 2019, 381(21), 2064-2066.
[http://dx.doi.org/10.1056/NEJMe1913807] [PMID: 31665573]

Aho, V.T.E.; Pereira, P.A.B.; Voutilainen, S.; Paulin, L.; Pekkonen, E.; Auvinen, P.; Scheperjans, F. Gut microbiota in Parkinson’s disease: Temporal stability and relations to disease progression. EBioMedicine, 2019, 44, 691-707.
[http://dx.doi.org/10.1016/j.ebiom.2019.05.064] [PMID: 31221587]

Boertien, J.M.; Pereira, P.A.B.; Aho, V.T.E.; Scheperjans, F. Increasing comparability and utility of gut microbiome studies in parkinson’s disease: A systematic review. J. Parkinsons Dis., 2019, 9(s2), S297-S312.
[http://dx.doi.org/10.3233/JPD-191711] [PMID: 31498131]

Liu, B.; Pedersen, N.L.; Tillander, A.; Ludvigsson, J.F.; Ekbom, A.; Svenningsson, P.; Chen, H.; Wirdefeldt, K. Vagotomy and Parkinson disease: A Swedish register-based matched-cohort study. Neurology, 2017, 88(21), 1996-2002.

Mulik, C.; Scott, H.; Inglis, D.; Montina, T.; Metz, G. Transgenerational effects of ancestral prenatal stress on the gut-brain axis. Alberta Acad. Rev., 2019, 2, 18.
[http://dx.doi.org/10.29173/aar109]

Manouthakis, E. Bioengineered in vitro enteric nervous system. J. Tissue Eng. Regen. Med., 2019, 13(9), 1712-1723.