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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Systematic Review Article

纳米医学：乳腺癌有效疗法发展的有希望的途径

卷 20, 期 8, 2020

页: [603 - 615] 页: 13

弟呕挨: 10.2174/1568009620666200331124113

价格: $65

摘要

目的：乳腺癌是女性中最可能的癌症。 然而，可用的治疗是基于针对乳腺癌的不同阶段，即放射治疗，激素治疗，化学疗法和外科手术干预，这具有一定的局限性。 可用的化学疗法与诸如低溶解度，低渗透性，高首过代谢和P-糖蛋白外排等问题相关。 因此，上述限制导致无效的治疗。 多种化学疗法也可引起肿瘤抵抗。 因此，目的是通过应用纳米医学方法来开发治疗乳腺癌的有效治疗方案。 方法：本评价是根据系统的搜索策略进行的，基于截至2019年11月在Pub Med，MedlinePlus，Google Scholar和Sciencedirect上可用的相关文献，使用了摘要中存在的关键字和标题。 根据我们的纳入和排除标准，筛选了226篇文章。 在226篇文章中，总共选择了40篇文章进行此评价。 结果：目前可利用的治疗方法的重要发现是该药物除了分布到靶标特异性部位外，还分布到健康细胞中，导致严重的副作用。 而且，该药物在作用部位的生物利用度较低。 因此，为了克服这个问题，需要高剂量，这又会引起副作用并降低益处。 纳米医学方法提供了另一种方法来避免可利用的化学疗法治疗乳腺癌的相关问题。 结论：纳米药物策略可用于常规乳腺癌治疗，并使用不同的新型药物递送方法来递送靶标特异性药物。

关键词: 乳腺癌，化学疗法，生物利用度，副作用，受体靶标，纳米药物。

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