摘要
目的:研究Slit2和Robo1在多发性肌炎(PM)/皮肌炎(DM)血管疾病中的作用。 背景:PM和DM是非化脓性炎症性肌病,主要侵袭骨骼肌。 目的:本研究试图探讨Slit2 / Robo1信号通路蛋白在PM / DM血管疾病中的特异性机制。 方法:采用RT-qPCR检测新诊断的PM / DM患者与健康对照者肌肉组织中Slit2和Robo1的mRNA表达。用免疫组织化学法对10例PM,10例DM患者和20例健康对照者的肌肉石蜡组织连续切片中Slit2和Robo1阳性细胞的数量进行了测量。 结果:研究结果显示,PM组和DM组肌肉组织中Slit2和Robo1的mRNA表达高于对照组(P <0.05)。 PM和DM组肌肉组织中Slit2和Robo1的阳性表达率分别为80.0%,80.0%,70.0%和70.0%。与对照组相比,差异具有统计学意义(P <0.001)(阳性表达率分别为0%和10%)。结论:Slit2 / Robo1信号通路的激活是导致PM / DM发展的重要机制。
关键词: 多发性肌炎,皮肌炎,Slit2,Robo1,炎症,信号通路。
Current Molecular Medicine
Title:A Study Based on the Correlation Between Slit2/Robo1 Signaling Pathway Proteins and Polymyositis/Dermatomyositis
Volume: 20 Issue: 9
关键词: 多发性肌炎,皮肌炎,Slit2,Robo1,炎症,信号通路。
摘要:
Aims: To investigate the role of Slit2 and Robo1 during the vascular disease of Polymyositis (PM) / dermatomyositis (DM).
Background: PM and DM are nonsuppurative inflammatory myopathies that mainly invade the skeletal muscles.
Objective: This study attempted to explore the specific mechanism of Slit2/Robo1 signaling pathway proteins during the vascular disease of PM/DM.
Methods: The mRNA expressions of Slit2 and Robo1 in the muscle tissue were detected by RT-qPCR between newly-diagnosed PM/DM patients and healthy controls. The number of Slit2 and Robo1 positive cells in the serial sections of muscle paraffin tissues was measured by immunohistochemistry in 10 patients with PM, 10 patients with DM and 20 healthy controls.
Results: The study results revealed that the mRNA expressions of Slit2 and Robo1 in muscle tissue in the PM and DM groups were higher than that in the control group (P<0.05). The positive expression rates of Slit2 and Robo1 in muscle tissue in the PM and DM groups were 80.0%, 80.0%, 70.0% and 70.0%, respectively. The difference was statistically significant (P<0.001), when compared to the control group (the positive expression rates were 0% and 10%, respectively).
Conclusion: The activation of the Slit2/Robo1 signaling pathway is an important mechanism leading to the development of PM/DM.
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Cite this article as:
A Study Based on the Correlation Between Slit2/Robo1 Signaling Pathway Proteins and Polymyositis/Dermatomyositis, Current Molecular Medicine 2020; 20 (9) . https://dx.doi.org/10.2174/1566524020666200326102837
DOI https://dx.doi.org/10.2174/1566524020666200326102837 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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